Core-shell microspheres by dispersion polymerization as promising delivery systems for proteins.

Core-shell microspheres by dispersion polymerization as promising delivery systems for proteins. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Core-shell microspheres by dispersion polymerization as promising delivery systems for proteins. Abstract Text:

Katia Sparnacci,Michele Laus,Luisa Tondelli,Cinzia Bernardi,Laura Magnani,Franco Corticelli,Marco Marchisio,Barbara Ensoli,Arianna Castaldello,Antonella Caputo,

Functional poly(methyl methacrylate) core-shell microspheres were prepared by dispersion polymerization. An appropriate selection of experimental parameters and in particular of the initiator and stabilizer amount and of the medium solvency power allowed a monodisperse sample as large as 600 nm to be prepared. To this purpose, low initiator concentration, high steric stabilizer amount and a low solvency power medium were employed. The microspheres present a core-shell structure in which the outer shell is constituted by the steric stabilizer which affords carboxylic groups able to interact with basic proteins, such as trypsin, whose adsorption is essentially driven by the carboxylic group density in the microsphere shell. Finally, fluorescent microspheres were prepared for biodistribution studies and shown to be readily taken up by the cells both in vitro and in vivo. These results suggest that these microspheres are promising delivery systems for the development of novel protein-based vaccines.

Core-shell microspheres by dispersion polymerization as promising delivery systems for proteins. Publishing Authors By Initials

K Sparnacci,M Laus,L Tondelli,C Bernardi,L Magnani,F Corticelli,M Marchisio,B Ensoli,A Castaldello,A Caputo,

For similar enzymes and coenzymes: enzymes: hydrolases: peptide hydrolases: endopeptidases: serine endopeptidases: trypsin research abstracts see: enzymes and coenzymes: enzymes: hydrolases: peptide hydrolases: endopeptidases: serine endopeptidases: trypsin research

PUBMED ID PMID:

MEDLINE DATE:

Core-shell microspheres by dispersion polymerization as promising delivery systems for proteins. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of biomaterials science. Polymer edition

VOLUME: 16

Page Numbers: 1557-74

Journal Abbreviation:

ISSN: 0920-5063

DAY: 20

MONTH: 02

YEAR: 2005

Core-shell microspheres by dispersion polymerization as promising delivery systems for proteins. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9007393

Core-shell microspheres by dispersion polymerization as promising delivery systems for proteins. Keywords Mesh Terms:

KEYWORDS: Trypsin

MESH TERMS: pharmacokinetics

Chemical & Substance for Abstract: Core-shell microspheres by dispersion polymerization as promising delivery systems for proteins. Information

Substance Name: Trypsin

Registry Number: EC 3.4.21.4

Grant and Affiliation Information for Core-shell microspheres by dispersion polymerization as promising delivery systems for proteins.

AFFILIATION: Department of Environmental and Life Sciences INSTM, University of Piemonte Orientale, Spalto Marengo 33, 15100 Alessandria, Italy.

Country: Netherlands

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: J Biomater Sci Polym Ed

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Core-shell microspheres by dispersion polymerization as promising delivery systems for proteins Related Publications

• Chylothorax following cardiac surgery caused by unusual lymphatic anatomy.
• Core-shell microspheres by dispersion polymerization as promising delivery systems for proteins.
• Cytophagic histiocytic panniculitis and subcutaneous panniculitis-like T-cell lymphoma: report of 7 cases.
• Different types of DNA -synthesis and their importance in cancer growth and therapy.
• Diplopia in the aged: etiology and management.
• Further investigations on the behavior of cultivated salivary gland adenocarcinoma of the mouse.
• Generalized granuloma annulare and eruptive folliculitis in an HIV-positive man: resolution after antiretroviral therapy.
• Health and street/ homeless youth.
• Insights into the interaction of sortilin with proneurotrophins: A computational approach.
• Molecular phylogeny of the three paedomorphic mediterranean gobies (Perciformes: Gobiidae).
• Multiple erythematous plaques on a child. Acute hemorrhagic edema (AHE) of infancy.
• Not Available
• Oxygen consumption, heart rate, rating of perceived exertion, and systolic blood pressure with water treadmill walking.
• Phylogeographic inferences from the mtDNA variation of the three-toed skink, Chalcides chalcides (Reptilia: Scincidae).
• Physical Fitness and Academic Achievement in Elementary School Children: 2214: Board #127 June 1 9:00 AM - 10:30 AM.
• Production of cromolyn sodium microparticles for aerosol delivery by supercritical assisted atomization.
• Quantification of metamorphopsia in patients with epiretinal membranes before and after surgery.
• Role of MR imaging in acquired and congenital cardiovascular disease.
• Stratification for the propensity score compared with linear regression techniques to assess the effect of treatment or exposure.
• The use of CalciumOrange-5N as a specific marker of mitochondrial Ca(2+) in mouse skeletal muscle fibers.
• Widespread idiopathic pyoderma gangrenosum evolved from ulcerative to vegetative type: a 10-year history with a recent response to infliximab.
• ["Perioral dermatitis" in children and adults]
• [Congenital erythrodermal states in childhood]
• [Langerhans cells in histiocytosis. X. Their changes caused by vincoblastine]
• [On the presence of unusual intranuclear microbodies in mucosynechiant and atrophbic bullous dermatitis. Electron microscopic observations]
• [Photoelastic analysis of bite force on teeth- and mucous membrane supported removable prostheses]
• [The dermo-epidermal junction in mucosynechial and atrophic dermatitis bullosa]
• [Ultrastructural aspects of Duhring's herpetiform dermatitis]
• [Ultrastructural aspects of the bullous lesion in polymorphous erythema]
• pH-sensitive vesicles containing a lipidic beta-amino acid with two hydrophobic chains.