Copper-catalyzed N-arylation of imidazoles and benzimidazoles.

Copper-catalyzed N-arylation of imidazoles and benzimidazoles. Research Abstract Details 

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Copper-catalyzed N-arylation of imidazoles and benzimidazoles. Abstract Text:

Ryan A Altman,Erica D Koval,Stephen L Buchwald,

4,7-Dimethoxy-1,10-phenanthroline (L1c) was found to be an efficient ligand for the copper-catalyzed N-arylation of imidazoles and benzimidazoles with both aryl iodides and bromides under mild conditions. Further optimization of the system has revealed that the addition of poly(ethylene glycol) accelerates this reaction. A variety of hindered and functionalized imidazoles, benzimidazoles, and aryl halides were transformed in good to excellent yields. Heteroaryl halides were also coupled in moderate to good yields. We also present the results obtained from a series of coupling reactions, which directly compare the use of L1c with other recently reported ligands.

Copper-catalyzed N-arylation of imidazoles and benzimidazoles. Publishing Authors By Initials

RA Altman,ED Koval,SL Buchwald,

For similar organic chemicals: alcohols: glycols: ethylene glycols: polyethylene glycols research abstracts see: organic chemicals: alcohols: glycols: ethylene glycols: polyethylene glycols research

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Copper-catalyzed N-arylation of imidazoles and benzimidazoles. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: The Journal of organic chemistry

VOLUME: 72

Page Numbers: 6190-9

Journal Abbreviation: J. Org. Chem.

ISSN: 0022-3263

DAY: 11

MONTH: 07

YEAR: 2007

Copper-catalyzed N-arylation of imidazoles and benzimidazoles. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 2985193

Copper-catalyzed N-arylation of imidazoles and benzimidazoles. Keywords Mesh Terms:

KEYWORDS: Polyethylene Glycols

MESH TERMS: chemistry

Chemical & Substance for Abstract: Copper-catalyzed N-arylation of imidazoles and benzimidazoles. Information

Substance Name: Copper

Registry Number: 7440-50-8

Grant and Affiliation Information for Copper-catalyzed N-arylation of imidazoles and benzimidazoles.

AFFILIATION: Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

Country: United States

AGENCY: United States NIGMS

GRANT: GM 58160

ACRONYM: GM

MEDLINETA: J Org Chem

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