Copper-catalyzed halogen exchange in aryl halides: an aromatic Finkelstein reaction.

Copper-catalyzed halogen exchange in aryl halides: an aromatic Finkelstein reaction. Research Abstract Details 

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Copper-catalyzed halogen exchange in aryl halides: an aromatic Finkelstein reaction. Abstract Text:

Artis Klapars,Stephen L Buchwald,

A mild and general method for the conversion of aryl, heteroaryl, and vinyl bromides into the corresponding iodides was developed utilizing a catalyst system comprising 5 mol % of CuI and 10 mol % of a 1,2- or 1,3-diamine ligand. A variety of polar functional groups are tolerated, and even N-H containing substrates such as sulfonamides, amides, and indoles are compatible with the reaction conditions. Both the reaction rate and the equilibrium conversion of the aryl bromide depend on the choice of the halide salt and the solvent. The best results were obtained using NaI as the halide salt and dioxane, n-butanol, or n-pentanol as the solvents.

Copper-catalyzed halogen exchange in aryl halides: an aromatic Finkelstein reaction. Publishing Authors By Initials

A Klapars,SL Buchwald,

For similar chemical and pharmacologic phenomena: kinetics research abstracts see: chemical and pharmacologic phenomena: kinetics research

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Copper-catalyzed halogen exchange in aryl halides: an aromatic Finkelstein reaction. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Journal of the American Chemical Society

VOLUME: 124

Page Numbers: 14844-5

Journal Abbreviation: J. Am. Chem. Soc.

ISSN: 0002-7863

DAY: 18

MONTH: Dec

YEAR: 2002

Copper-catalyzed halogen exchange in aryl halides: an aromatic Finkelstein reaction. Information

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LANGUAGE: eng

NlmUniqueID: 7503056

Copper-catalyzed halogen exchange in aryl halides: an aromatic Finkelstein reaction. Keywords Mesh Terms:

KEYWORDS: Kinetics

MESH TERMS: chemistry

Chemical & Substance for Abstract: Copper-catalyzed halogen exchange in aryl halides: an aromatic Finkelstein reaction. Information

Substance Name: Copper

Registry Number: 7440-50-8

Grant and Affiliation Information for Copper-catalyzed halogen exchange in aryl halides: an aromatic Finkelstein reaction.

AFFILIATION: Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.

Country: United States

AGENCY: United States NIGMS

GRANT: GM 45906

ACRONYM: GM

MEDLINETA: J Am Chem Soc

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