Copper-aspirin complex inhibits cyclooxygenase-2 more selectively than aspirin.

Copper-aspirin complex inhibits cyclooxygenase-2 more selectively than aspirin. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Copper-aspirin complex inhibits cyclooxygenase-2 more selectively than aspirin. Abstract Text:

Yu Yun,Peng Chen,Chun Lan Zheng,Yong Yang,Wei Gang Duan,Lei Wang,Bo He,Jia Qing Ma,Dian Hua Wang,Zhi Qiang Shen,Yu Yun,Peng Chen,Chun Lan Zheng,Yong Yang,Wei Gang Duan,Lei Wang,Bo He,Jia Qing Ma,Dian Hua Wang,Zhi Qiang Shen,

The antiinflammatory effects of the copper-aspirin complex (Cu-Asp) were more potent than that of Asp in rats or mice with fewer classic adverse effects. The aim of this study was to determine the cause by evaluating Cu-Asp selective inhibition on cyclooxygenases (COX). COX-1 inhibition was evaluated based on 6-keto-prostaglandin F(1alpha) (6-keto-PGF(1alpha)) in an endothelial cell model, and COX-2 inhibition was based on prostaglandin E(2) (PGE(2)) in a macrophage model. Radioimmunoassay (RIA) was applied to determine 6-keto-PGF(1alpha) in resting human umbilical vein endothelial cell line (ECV304), and PGE(2) in activated macrophages. The results showed that the inhibition of 6-keto-PGF(1alpha) yield by Cu-Asp (3 to 0.01 mM) was markedly weaker than that by aspirin (Asp); while the inhibition of PGE(2) yield by Cu-Asp (10 to 0.1 mM) was significantly stronger than that by Asp. Based on the inhibition on 6-keto-PGF(1alpha) and PGE(2), the medium inhibitory concentration (IC(50)) of Cu-Asp on COX-1 and on COX-2 was 1.03+/-0.15 mM, and 0.32+/-0.04 mM, respectively. The selective inhibition index on COX-2, IC(50) (COX-1)/IC(50) (COX-2), of Cu-Asp was 3.33+/-0.89, while that of Asp was 0.42+/-0.12. The results suggest that, unlike Asp, Cu-Asp is a relatively selective inhibitor of COX-2 in the present models; the selectivity of Cu-Asp is about seven-fold greater than that of Asp.

Copper-aspirin complex inhibits cyclooxygenase-2 more selectively than aspirin. Publishing Authors By Initials

Y Yun,P Chen,CL Zheng,Y Yang,WG Duan,L Wang,B He,JQ Ma,DH Wang,ZQ Shen,Y Yun,P Chen,CL Zheng,Y Yang,WG Duan,L Wang,B He,JQ Ma,DH Wang,ZQ Shen,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Copper-aspirin complex inhibits cyclooxygenase-2 more selectively than aspirin. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Yakugaku zasshi : Journal of the Pharmaceutical So

VOLUME: 127

Page Numbers: 1869-75

Journal Abbreviation: Yakugaku Zasshi

ISSN: 0031-6903

DAY: 5

MONTH: Nov

YEAR: 2007

Copper-aspirin complex inhibits cyclooxygenase-2 more selectively than aspirin. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 413613

Copper-aspirin complex inhibits cyclooxygenase-2 more selectively than aspirin. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Copper-aspirin complex inhibits cyclooxygenase-2 more selectively than aspirin. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Copper-aspirin complex inhibits cyclooxygenase-2 more selectively than aspirin.

AFFILIATION: Yunnan Pharmacological Laboratories of Natural Products, Kunming Medical College, Western People's Road, Kunming, PR China.

Country: Japan

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Yakugaku Zasshi

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Copper-aspirin complex inhibits cyclooxygenase-2 more selectively than aspirin Related Publications

• Comment on "Direct measurement of the 'Giant' adiabatic temperature change in Gd5Si2Ge2".
• Comparison of IL-6-induced STAT1 activation in different responsive cells.
• [Advanced life support in prehospital emergency treatment of trauma]
• [Application of long distance-PCR to hemophilia A carrier detection and prenatal diagnosis]
• [Cell cycle analysis and P53 gene mutation detection of fibroblasts derived from the surrounding skin of keloids]
• [Clinical investigation of application of lung biopsy in the diagnosis of diffuse pulmonary interstitial disease]
• [Continuous target of China's manned space project and research direction of space medico-engineering]
• [Coronary artery bypass grafting after acute myocardial infarction]
• [Development of an anti-rTNF-alpha chimeric antibody]
• [Effect of staining method and sintering temperature on the color of porcelain-fused-to-metal restorations]
• [Effects of microgravity on human cognitive function in space flight]
• [Epidemic investigation on 3 to 6 years children's bruxism in Shanghai.]
• [Epidemiology and drug resistance of the pathogenic microbes in the complicated infection of hematological malignancies]
• [European Society of cardiology guideline (III): percutaneous coronary interventions Emergency department]
• [Expectation of the study of weightlessness physiology in the 21st century]
• [Expression of adhesion molecules on CD34(+) hematopoietic precursor cells from normal human bone marrow, cord blood and mobilized blood]
• [Expression of monoclonal nonspecific suppressor factor beta in E. coli, preparation of its antibodies and its tissue orientation in the mouse endometrium]
• [Fiberoptic ductoscopy for patients with intraductal papillary lesions]
• [Non-extraction approach using RPE to correct Angle Class I malocclusion with moderate crowding: A cephalometric study]
• [Observation on the effects of urapidil on hemodynamics in heart dysfunction dogs by thoracic electrical bioimpedance]
• [Relationship between the human zygote type and embryo implantation potential]
• [Relationship of vitamin D receptor polymorphism with breast cancer]
• [Science face upto to fact of undiscovered, frustration and challenge from severe acute respiratory syndrome]
• [Site-specific mutagenesis of murine anti-human TNF-alpha Fab gene and its expression in E.coli]
• [Study on the mechanism of the effects of recombinant rat tumor necrosis factor alpha on the degradation of rat skeletal muscle proteins]
• [Study on the relationship between sulfonylurea receptor 1 gene polymorphism and type 2 diabetes mellitus]
• [Superiority of traditional Chinese medicine on gene regulation]
• [The epidemiological study of severe acute respiratory syndrome]
• [Transfer and expression of rh-SCF gene in human hematopoietic stem/progenitor cells]
• [Treatment of AMI with ST segment hoist]