Coordination of development and metabolism in the pre-midblastula transition zebrafish embryo.

Coordination of development and metabolism in the pre-midblastula transition zebrafish embryo. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Coordination of development and metabolism in the pre-midblastula transition zebrafish embryo. Abstract Text:

To define the mechanisms that coordinate early embryonic development and metabolism, we have examined the response of zebrafish embryos to anoxia before the midblastula transition. Our findings reveal that anoxic pre-midblastula transition embryos slow the cell cycle, arrest before the midblastula transition and can recover normally if restored to a normoxic environment. Analyses of respiratory rates reveal that pre-midblastula transition embryos are less reliant on oxidative phosphorylation than older embryos. Interestingly, arrest in anoxia occurs despite inhibition of zygotic transcription, revealing a central role for maternal factors in the response to energy limitation. Consistent with this concept, we demonstrate that the posttranslational energy-sensing AMP-activated protein kinase pathway is activated in anoxia in pre-midblastula transition embryos. Taken together, these findings demonstrate a maternal program capable of coordinating developmental rate and metabolism in the absence of transcription-based pathways or cell cycle checkpoints. Developmental Dynamics 237:1789-1798, 2008. (c) 2008 Wiley-Liss, Inc.

Coordination of development and metabolism in the pre-midblastula transition zebrafish embryo. Publishing Authors By Initials

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Coordination of development and metabolism in the pre-midblastula transition zebrafish embryo. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Developmental dynamics : an official publication o

VOLUME: 237

Page Numbers: 1789-98

Journal Abbreviation: Dev. Dyn.

ISSN: 1058-8388

DAY: 30

MONTH: Jul

YEAR: 2008

Coordination of development and metabolism in the pre-midblastula transition zebrafish embryo. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9201927

Coordination of development and metabolism in the pre-midblastula transition zebrafish embryo. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Coordination of development and metabolism in the pre-midblastula transition zebrafish embryo. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Coordination of development and metabolism in the pre-midblastula transition zebrafish embryo.

AFFILIATION: Edward Mallinckrodt Department of Pediatrics, Washington University School of Medicine, St. Louis, Missouri.

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Dev Dyn

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Coordination of development and metabolism in the pre-midblastula transition zebrafish embryo Related Publications

• ATAXIA TELANGIECTASIS. A DYSGAMMAGLOBULINAEMIA WITH DEFICIENT GAMMA-1-A (BETA-2-A)-GLOBULIN.
• Assembling the pieces.
• Atomic energy or the atomic bomb; a problem in the development or morale and opinion.
• Augmentation strategies in the treatment of major depressive disorder. Clinical considerations with atypical antipsychotic augmentation.
• Coordination of development and metabolism in the pre-midblastula transition zebrafish embryo.
• Copper and iron disorders of the brain.
• Copper deficiency.
• Dysgammaglobulinaemia and recurrent bacterial infection.
• Essential role for fibrillin-2 in zebrafish notochord and vascular morphogenesis.
• Essential role of lysyl oxidases in notochord development.
• Further characterization of IgG receptors from human placenta.
• In vivo correction of a Menkes disease model using antisense oligonucleotides.
• Intracellular localization of the Menkes and Wilson's disease proteins and their role in intracellular copper transport.
• The zebrafish embryo as a dynamic model of anoxia tolerance.
• Use of ultraviolet absorption spectroscopy in the quantitative precipitin reaction.
• Zieve's syndrome and porphyrinuria in an alcoholic.