Coordination chemical studies on metalloenzymes. Kinetics and mechanism of the Zn(II) exchange reaction between chelating agent and apo-bovine carbonic anhydrase.

Coordination chemical studies on metalloenzymes. Kinetics and mechanism of the Zn(II) exchange reaction between chelating agent and apo-bovine carbonic anhydrase. Research Abstract Details 

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Coordination chemical studies on metalloenzymes. Kinetics and mechanism of the Zn(II) exchange reaction between chelating agent and apo-bovine carbonic anhydrase. Abstract Text:

Y Kidani,J Hirose,H Koike,

The mechanism of removal of the zinc ion from bovine carbonic anhydrase [EC 4.2.1.1] (BCA) by a chelating agent was studied. It was shown that the removal of the zinc ion from BCA took place through the formation of a ternary complex involving the enzyme, chelating agent, and metal ions. The formation constant of the ternary complex (KEML) was 10(2) M-1. This value was lower than the formation constant assumed by Wilkins. The reaction of zinc-2, 6-pyridinedicarboxylate complex with the apoenzyme also took place through the formation of the ternary complex and the species which reacted with apo-BCA was a 1:1 complex of zinc and 2, 6-pyridine-dicarboxylate. The theoretical equilibrium equation derived from the reaction mechanism showed a good fit with observed equilibrium dialysis data.

Coordination chemical studies on metalloenzymes. Kinetics and mechanism of the Zn(II) exchange reaction between chelating agent and apo-bovine carbonic anhydrase. Publishing Authors By Initials

Y Kidani,J Hirose,H Koike,

For similar inorganic chemicals: elements: metals, heavy: zinc research abstracts see: inorganic chemicals: elements: metals, heavy: zinc research

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Coordination chemical studies on metalloenzymes. Kinetics and mechanism of the Zn(II) exchange reaction between chelating agent and apo-bovine carbonic anhydrase. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of biochemistry

VOLUME: 79

Page Numbers: 43-51

Journal Abbreviation: J. Biochem.

ISSN: 0021-924X

DAY: 19

MONTH: Jan

YEAR: 1976

Coordination chemical studies on metalloenzymes. Kinetics and mechanism of the Zn(II) exchange reaction between chelating agent and apo-bovine carbonic anhydrase. Information

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LANGUAGE: eng

NlmUniqueID: 376600

Coordination chemical studies on metalloenzymes. Kinetics and mechanism of the Zn(II) exchange reaction between chelating agent and apo-bovine carbonic anhydrase. Keywords Mesh Terms:

KEYWORDS: Zinc

MESH TERMS: pharmacology

Chemical & Substance for Abstract: Coordination chemical studies on metalloenzymes. Kinetics and mechanism of the Zn(II) exchange reaction between chelating agent and apo-bovine carbonic anhydrase. Information

Substance Name: Carbonic Anhydrases

Registry Number: EC 4.2.1.1

Grant and Affiliation Information for Coordination chemical studies on metalloenzymes. Kinetics and mechanism of the Zn(II) exchange reaction between chelating agent and apo-bovine carbonic anhydrase.

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Country: JAPAN

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MEDLINETA: J Biochem

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