Coordinating structural and functional synapse development: postsynaptic p21-activated kinase independently specifies glutamate receptor abundance and postsynaptic morphology.

Coordinating structural and functional synapse development: postsynaptic p21-activated kinase independently specifies glutamate receptor abundance and postsynaptic morphology. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Coordinating structural and functional synapse development: postsynaptic p21-activated kinase independently specifies glutamate receptor abundance and postsynaptic morphology. Abstract Text:

Stephanie D Albin,Graeme W Davis,

Here, we show that postsynaptic p21-activated kinase (Pak) signaling diverges into two genetically separable pathways at the Drosophila neuromuscular junction. One pathway controls glutamate receptor abundance. Pak signaling within this pathway is specified by a required interaction with the adaptor protein Dreadlocks (Dock). We demonstrate that Dock is localized to the synapse via an Src homology 2-mediated protein interaction. Dock is not necessary for Pak localization but is necessary to restrict Pak signaling to control glutamate receptor abundance. A second genetically separable function of Pak kinase signaling controls muscle membrane specialization through the regulation of synaptic Discs-large. In this pathway, Dock is dispensable. We present a model in which divergent Pak signaling is able to coordinate two different features of postsynaptic maturation, receptor abundance, and muscle membrane specialization.

Coordinating structural and functional synapse development: postsynaptic p21-activated kinase independently specifies glutamate receptor abundance and postsynaptic morphology. Publishing Authors By Initials

SD Albin,GW Davis,

For similar enzymes and coenzymes: enzymes: transferases: phosphotransferases: phosphotransferases (alcohol group acceptor): protein kinases: protein-serine-threonine kinases: p21-activated kinases research abstracts see: enzymes and coenzymes: enzymes: transferases: phosphotransferases: phosphotransferases (alcohol group acceptor): protein kinases: protein-serine-threonine kinases: p21-activated kinases research

PUBMED ID PMID:

MEDLINE DATE:

Coordinating structural and functional synapse development: postsynaptic p21-activated kinase independently specifies glutamate receptor abundance and postsynaptic morphology. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: The Journal of neuroscience : the official journal

VOLUME: 24

Page Numbers: 6871-9

Journal Abbreviation: J. Neurosci.

ISSN: 1529-2401

DAY: 4

MONTH: Aug

YEAR: 2004

Coordinating structural and functional synapse development: postsynaptic p21-activated kinase independently specifies glutamate receptor abundance and postsynaptic morphology. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8102140

Coordinating structural and functional synapse development: postsynaptic p21-activated kinase independently specifies glutamate receptor abundance and postsynaptic morphology. Keywords Mesh Terms:

KEYWORDS: p21-Activated Kinases

MESH TERMS: physiology

Chemical & Substance for Abstract: Coordinating structural and functional synapse development: postsynaptic p21-activated kinase independently specifies glutamate receptor abundance and postsynaptic morphology. Information

Substance Name: GTP Phosphohydrolases

Registry Number: EC 3.6.1.-

Grant and Affiliation Information for Coordinating structural and functional synapse development: postsynaptic p21-activated kinase independently specifies glutamate receptor abundance and postsynaptic morphology.

AFFILIATION: Department of Biochemistry and Biophysics, Program in Neuroscience, University of California, San Francisco, San Francisco, California 94143, USA.

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: J Neurosci

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Coordinating structural and functional synapse development: postsynaptic p21-activated kinase independently specifies glutamate receptor abundance and postsynaptic morphology Related Publications

• A new prognostic index in surgery and parenteral feeding: the ratio of triiodothyronine to reverse triiodothyronine in serum (T(3)/rT(3) ratio).
• A postsynaptic spectrin scaffold defines active zone size, spacing, and efficacy at the Drosophila neuromuscular junction.
• Adenovirus-mediated BMP2 expression in human bone marrow stromal cells.
• Baxter allegiance prize acceptance.
• Cerebral metastases in malignant mesothelioma: case report and literature review.
• Childhood nephrosis.
• Comparison of the gross motor function measure and paediatric evaluation of disability inventory in assessing motor function in children undergoing selective dorsal rhizotomy.
• Coordinate transcriptional repression of liver fatty acid-binding protein and microsomal triglyceride transfer protein blocks hepatic very low density lipoprotein secretion without hepatosteatosis.
• Coordinating structural and functional synapse development: postsynaptic p21-activated kinase independently specifies glutamate receptor abundance and postsynaptic morphology.
• Cytokines, infections, stress, and dysphoric moods in breastfeeders and formula feeders.
• Development of pig blastocysts in vitro is altered by serum, bovine serum albumin and amino acids and vitamins.
• Drinking in the year after treatment as a predictor of three-year drinking outcomes.
• Emotion, motivation, and the brain: reflex foundations in animal and human research.
• Evidence for novel pH-dependent regulation of Candida albicans Rim101, a direct transcriptional repressor of the cell wall beta-glycosidase Phr2.
• Fc receptor homolog 3 is a novel immunoregulatory marker of marginal zone and B1 B cells.
• Female gamete preservation.
• Is Doppler ultrasound sufficient as the sole investigation before carotid endarterectomy?
• Lack of access to good healthcare & obese African-American women.
• Long-term outcomes in chronically hospitalized geriatric patients with schizophrenia: retrospective comparison of first generation and second generation antipsychotics.
• Measurement of the adhesion force between carbon nanotubes and a silicon dioxide substrate.
• Mechanisms underlying the rapid induction and sustained expression of synaptic homeostasis.
• Molecular inversion probe analysis of gene copy alterations reveals distinct categories of colorectal carcinoma.
• Osteoinduction by ex vivo adenovirus-mediated BMP2 delivery is independent of cell type.
• Perceptual and acoustic evidence of speaker adaptation to a thin pseudopalate.
• Physiologic, bronchoscopic, and bronchoalveolar lavage fluid findings in young children with recurrent wheeze and cough.
• Roles for Drosophila mushroom body neurons in olfactory learning and memory.
• Simultaneous shear and pressure sensor array for assessing pressure and shear at foot/ground interface.
• The effect of gonadal hormones and gender on anxiety and emotional learning.
• Use of a chimeric adenovirus vector enhances BMP2 production and bone formation.
• Women's responses to sexual aggression: the effects of childhood trauma, alcohol, and prior relationship.