Coordinated Muc2 and Muc3 mucin gene expression in Trichinella spiralis infection in wild-type and cytokine-deficient mice.

Coordinated Muc2 and Muc3 mucin gene expression in Trichinella spiralis infection in wild-type and cytokine-deficient mice. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Coordinated Muc2 and Muc3 mucin gene expression in Trichinella spiralis infection in wild-type and cytokine-deficient mice. Abstract Text:

L L Shekels,R E Anway,J Lin,M W Kennedy,P Garside,C E Lawrence,S B Ho,

Mucin hypersecretion is an important component of the immune response to gastrointestinal nematode infection. Two discrete types of mucin proteins exist in the mouse intestine, secretory Muc2 and membrane-bound Muc3. We examined Muc2 and Muc3 expression in wild-type mice and mice lacking gamma interferon receptor (IFNgammaR-/-), tumor necrosis factor receptor 1 (TNFR1-/-) and interleukin 4 (IL4-/-) infected with Trichinella spiralis. Infected wild-type mice demonstrated significant goblet cell hyperplasia and increased mucin glycoprotein. In situ hybridization showed this was accompanied by increases in Muc2 and Muc3 mRNA. Total intestinal mucin protein and Muc2 and Muc3 mRNA levels were also significantly increased in cytokine-deficient mice. These data demonstrate the coordinated up-regulation of two types of mucin genes in response to T. spiralis infection and may form the basis of an innate mucosal response independent of IFN-gamma, TNF, and IL-4.

Coordinated Muc2 and Muc3 mucin gene expression in Trichinella spiralis infection in wild-type and cytokine-deficient mice. Publishing Authors By Initials

LL Shekels,RE Anway,J Lin,MW Kennedy,P Garside,CE Lawrence,SB Ho,

For similar genetic processes: gene expression regulation: up-regulation research abstracts see: genetic processes: gene expression regulation: up-regulation research

PUBMED ID PMID:

MEDLINE DATE:

Coordinated Muc2 and Muc3 mucin gene expression in Trichinella spiralis infection in wild-type and cytokine-deficient mice. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Digestive diseases and sciences

VOLUME: 46

Page Numbers: 1757-64

Journal Abbreviation: Dig. Dis. Sci.

ISSN: 0163-2116

DAY: 1

MONTH: Aug

YEAR: 2001

Coordinated Muc2 and Muc3 mucin gene expression in Trichinella spiralis infection in wild-type and cytokine-deficient mice. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7902782

Coordinated Muc2 and Muc3 mucin gene expression in Trichinella spiralis infection in wild-type and cytokine-deficient mice. Keywords Mesh Terms:

KEYWORDS: Up-Regulation

MESH TERMS: metabolism

Chemical & Substance for Abstract: Coordinated Muc2 and Muc3 mucin gene expression in Trichinella spiralis infection in wild-type and cytokine-deficient mice. Information

Substance Name: Interleukin-4

Registry Number: 207137-56-2

Grant and Affiliation Information for Coordinated Muc2 and Muc3 mucin gene expression in Trichinella spiralis infection in wild-type and cytokine-deficient mice.

AFFILIATION: Department of Medicine, Veterans Affairs Medical Center and University of Minnesota, Minneapolis 55417, USA.

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Dig Dis Sci

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Coordinated Muc2 and Muc3 mucin gene expression in Trichinella spiralis infection in wild-type and cytokine-deficient mice Related Publications

• Adhesion of hematopoietic progenitor cells to human mesenchymal stem cells as a model for cell-cell interaction.
• Ageing and ART: a waste of time and money?
• An in vitro model of morphine withdrawal manifests the enhancing effect on human immunodeficiency virus infection of human T lymphocytes through the induction of substance P.
• Apigenin suppresses cancer cell growth through ERbeta.
• Bandgap-assisted surface-plasmon sensing.
• Characterization of mucins in human middle ear and Eustachian tube.
• Characterization of the mouse Muc3 membrane bound intestinal mucin 5' coding and promoter regions: regulation by inflammatory cytokines.
• Cloning and characterization of mouse intestinal MUC3 mucin: 3' sequence contains epidermal-growth-factor-like domains.
• Concurrent laparoscopic right hemicolectomy and ultra-low anterior resection with colonic J-pouch anal anastomosis for synchronous carcinoma.
• Coordinated Muc2 and Muc3 mucin gene expression in Trichinella spiralis infection in wild-type and cytokine-deficient mice.
• Developmental estrogen exposures predispose to prostate carcinogenesis with aging.
• Directing macromolecular conformation through halogen bonds.
• Directly measured insulin resistance and the assessment of clustered cardiovascular risks in hypertension.
• Does certificate of need affect cardiac outcomes and costs?
• Effects of lipid association on lomustine (CCNU) administered intracerebrally to syngeneic 36B-10 rat brain tumors.
• Expression of mucins in mucoid otitis media.
• Feasibility of weekly HIV drug delivery to enhance drug localization in lymphoid tissues based on pharmacokinetic models of lipid-associated indinavir.
• Health-seeking patterns among Chinese immigrant patients enrolled in the directly observed therapy program in New York City.
• High-resolution dynamic imaging of contrast agent uptake in a beating heart.
• MRI detection of macrophages labeled using micrometer-sized iron oxide particles.
• Methamphetamine-induced behavioral sensitization in mice: alterations in mu-opioid receptor.
• Natural killer cell inhibits human immunodeficiency virus replication in chronically infected immune cells.
• Orientation of deoxyhemoglobin at high magnetic fields: structural insights from RDCs in solution.
• Overexpression of mitochondrial superoxide dismutase in mice protects the retina from diabetes-induced oxidative stress.
• Repression of the hindbrain developmental program by Cdx factors is required for the specification of the vertebrate spinal cord.
• Spectroscopic evaluation of human tear lipids.
• Sulforaphane retards the growth of human PC-3 xenografts and inhibits HDAC activity in human subjects.
• Theoretical investigation of the mechanisms of reactions of H2CN and H2SiN with NO.
• Treatments of multi-invasive giant prolactinoma.
• Xanthohumol, a prenylflavonoid derived from hops induces apoptosis and inhibits NF-kappaB activation in prostate epithelial cells.