Coordinate modulation of melanogenesis and type I trimer collagen secretion by type I collagen substratum during reversible conversion between melanotic and amelanotic cells in mouse B16 melanoma.

Coordinate modulation of melanogenesis and type I trimer collagen secretion by type I collagen substratum during reversible conversion between melanotic and amelanotic cells in mouse B16 melanoma. Research Abstract Details 

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Coordinate modulation of melanogenesis and type I trimer collagen secretion by type I collagen substratum during reversible conversion between melanotic and amelanotic cells in mouse B16 melanoma. Abstract Text:

A U Ishikoh,A Hayashi,I Tokimitsu,S Tajima,T Nishikawa,

Two clones, melanotic (M3) and amelanotic (A4) cells, were isolated from B16 mouse melanoma cells. The two clones exhibited distinct phenotypes in cell morphology, melanogenesis, and secretion of extracellular matrix, with preferential secretion of type I trimer collagen in A4 cells. Grown on type I collagen substratum, M3 cells were converted to cells exhibiting similar phenotypes to A4 cells. Subsequent culture of A4-like cells on plastic dishes resulted in the recovery of the initial M3 phenotypes. These results indicate that the reversible conversion between melanotic and amelanotic cells in B16 melanoma cells in vitro is controlled by type I collagen substratum and that modulation of cell shape, melanogenesis, and type I trimer collagen secretion during conversion were all coordinately and reversibly regulated. The results provide evidence that extracellular matrix can control the cell phenotypes in mouse B16 melanoma. Modulation of type I trimer collagen secretion by type I collagen substrate could be a useful model for studying the alpha 1(I) chain-specific regulatory mechanism.

Coordinate modulation of melanogenesis and type I trimer collagen secretion by type I collagen substratum during reversible conversion between melanotic and amelanotic cells in mouse B16 melanoma. Publishing Authors By Initials

AU Ishikoh,A Hayashi,I Tokimitsu,S Tajima,T Nishikawa,

For similar peptides: oligopeptides research abstracts see: peptides: oligopeptides research

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Coordinate modulation of melanogenesis and type I trimer collagen secretion by type I collagen substratum during reversible conversion between melanotic and amelanotic cells in mouse B16 melanoma. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of biochemistry

VOLUME: 116

Page Numbers: 610-4

Journal Abbreviation: J. Biochem.

ISSN: 0021-924X

DAY: 19

MONTH: Sep

YEAR: 1994

Coordinate modulation of melanogenesis and type I trimer collagen secretion by type I collagen substratum during reversible conversion between melanotic and amelanotic cells in mouse B16 melanoma. Information

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LANGUAGE: eng

NlmUniqueID: 376600

Coordinate modulation of melanogenesis and type I trimer collagen secretion by type I collagen substratum during reversible conversion between melanotic and amelanotic cells in mouse B16 melanoma. Keywords Mesh Terms:

KEYWORDS: Oligopeptides

MESH TERMS: secretion

Chemical & Substance for Abstract: Coordinate modulation of melanogenesis and type I trimer collagen secretion by type I collagen substratum during reversible conversion between melanotic and amelanotic cells in mouse B16 melanoma. Information

Substance Name: Collagen

Registry Number: 9007-34-5

Grant and Affiliation Information for Coordinate modulation of melanogenesis and type I trimer collagen secretion by type I collagen substratum during reversible conversion between melanotic and amelanotic cells in mouse B16 melanoma.

AFFILIATION: Department of Dermatology, Keio University School of Medicine, Toky.

Country: JAPAN

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MEDLINETA: J Biochem

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Coordinate modulation of melanogenesis and type I trimer collagen secretion by type I collagen substratum during reversible conversion between melanotic and amelanotic cells in mouse B16 melanoma Related Publications

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