Coordinate gene regulation during hematopoiesis is related to genomic organization.

Coordinate gene regulation during hematopoiesis is related to genomic organization. Research Abstract Details 

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Coordinate gene regulation during hematopoiesis is related to genomic organization. Abstract Text:

Steven T Kosak,David Scalzo,Sam V Alworth,Fusheng Li,Stephanie Palmer,Tariq Enver,James S J Lee,Mark Groudine,Steven T Kosak,David Scalzo,Sam V Alworth,Fusheng Li,Stephanie Palmer,Tariq Enver,James S J Lee,Mark Groudine,Steven T Kosak,David Scalzo,Sam V Alworth,Fusheng Li,Stephanie Palmer,Tariq Enver,James S J Lee,Mark Groudine,

Gene loci are found in nuclear subcompartments that are related to their expression status. For instance, silent genes are often localized to heterochromatin and the nuclear periphery, whereas active genes tend to be found in the nuclear center. Evidence also suggests that chromosomes may be specifically positioned within the nucleus; however, the nature of this organization and how it is achieved are not yet fully understood. To examine whether gene regulation is related to a discernible pattern of genomic organization, we analyzed the linear arrangement of co-regulated genes along chromosomes and determined the organization of chromosomes during the differentiation of a hematopoietic progenitor to erythroid and neutrophil cell types. Our analysis reveals that there is a significant tendency for co-regulated genes to be proximal, which is related to the association of homologous chromosomes and the spatial juxtaposition of lineage-specific gene domains. We suggest that proximity in the form of chromosomal gene distribution and homolog association may be the basis for organizing the genome for coordinate gene regulation during cellular differentiation.

Coordinate gene regulation during hematopoiesis is related to genomic organization. Publishing Authors By Initials

ST Kosak,D Scalzo,SV Alworth,F Li,S Palmer,T Enver,JS Lee,M Groudine,ST Kosak,D Scalzo,SV Alworth,F Li,S Palmer,T Enver,JS Lee,M Groudine,ST Kosak,D Scalzo,SV Alworth,F Li,S Palmer,T Enver,JS Lee,M Groudine,

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Coordinate gene regulation during hematopoiesis is related to genomic organization. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: PLoS biology

VOLUME: 5

Page Numbers: e309

Journal Abbreviation: PLoS Biol.

ISSN: 1545-7885

DAY: 20

MONTH: Nov

YEAR: 2007

Coordinate gene regulation during hematopoiesis is related to genomic organization. Information

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LANGUAGE: eng

NlmUniqueID: 101183755

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Grant and Affiliation Information for Coordinate gene regulation during hematopoiesis is related to genomic organization.

AFFILIATION: Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America. skosak@fhcrc.org

Country: United States

AGENCY: United States NHLBI

GRANT: HL65440

ACRONYM: HL

MEDLINETA: PLoS Biol

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