Cooperative mechanisms of mitotic spindle formation.

Cooperative mechanisms of mitotic spindle formation. Research Abstract Details 

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Cooperative mechanisms of mitotic spindle formation. Abstract Text:

Christopher B O'Connell,Alexey L Khodjakov,

Cooperativity is well known to promote the speed of some biochemical reactions by accelerating the activity of enzymes. Recent studies have shown that cooperative interactions also function during the formation of a complex cellular structure, the mitotic spindle. Capture of kinetochores by dynamic astral microtubules was originally proposed as the basis of spindle formation. However, mounting evidence indicates that a more complex series of events occurs. It is now clear that there are multiple microtubule nucleation and capture sites throughout the spindle. Kinetochores, centrosomes and microtubules play multiple roles in establishing connections between spindle components and integrating them into a common structure. These data support a modified search-and-capture model that incorporates additional assembly pathways coordinated by a RanGTP gradient.

Cooperative mechanisms of mitotic spindle formation. Publishing Authors By Initials

CB O'Connell,AL Khodjakov,

For similar enzymes and coenzymes: enzymes: hydrolases: acid anhydride hydrolases: gtp phosphohydrolases: gtp-binding proteins: monomeric gtp-binding proteins: ran gtp-binding protein research abstracts see: enzymes and coenzymes: enzymes: hydrolases: acid anhydride hydrolases: gtp phosphohydrolases: gtp-binding proteins: monomeric gtp-binding proteins: ran gtp-binding protein research

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Cooperative mechanisms of mitotic spindle formation. Journal Published:

PUBLICATION TYPE: Review

Journal: Journal of cell science

VOLUME: 120

Page Numbers: 1717-22

Journal Abbreviation: J. Cell. Sci.

ISSN: 0021-9533

DAY: 15

MONTH: May

YEAR: 2007

Cooperative mechanisms of mitotic spindle formation. Information

Number of References: 51

LANGUAGE: eng

NlmUniqueID: 52457

Cooperative mechanisms of mitotic spindle formation. Keywords Mesh Terms:

KEYWORDS: ran GTP-Binding Protein

MESH TERMS: metabolism

Chemical & Substance for Abstract: Cooperative mechanisms of mitotic spindle formation. Information

Substance Name: ran GTP-Binding Protein

Registry Number: EC 3.6.5.2

Grant and Affiliation Information for Cooperative mechanisms of mitotic spindle formation.

AFFILIATION: Division of Molecular Medicine, Wadsworth Center, New York State Department of Health, Albany, NY 12201-0509, USA. oconnell@wadsworth.org

Country: England

AGENCY: United States PHS

GRANT: GMS 59363

ACRONYM: GM

MEDLINETA: J Cell Sci

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