Cooperative catalysis of a cationic ruthenium complex, amine base, and na salt: catalytic activation of acetonitrile as a nucleophile.

Cooperative catalysis of a cationic ruthenium complex, amine base, and na salt: catalytic activation of acetonitrile as a nucleophile. Research Abstract Details 

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Cooperative catalysis of a cationic ruthenium complex, amine base, and na salt: catalytic activation of acetonitrile as a nucleophile. Abstract Text:

Naoya Kumagai,Shigeki Matsunaga,Masakatsu Shibasaki,

Cooperative catalysis of a cationic Ru complex, DBU, and NaPF6 is described. An exquisite combination of the catalytic triad enabled catalytic activation of acetonitrile as a nucleophile under mild amine-basic conditions. Addition of in situ-generated, Ru-bound, metalated nitrile to aldehydes and imines proceeded smoothly with 2.5-5 mol % Ru complex and 2.5-10 mol % DBU in the presence of 10 mol % NaPF6. Preliminary mechanistic studies suggested a role for each of the three catalytic components.

Cooperative catalysis of a cationic ruthenium complex, amine base, and na salt: catalytic activation of acetonitrile as a nucleophile. Publishing Authors By Initials

N Kumagai,S Matsunaga,M Shibasaki,

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Cooperative catalysis of a cationic ruthenium complex, amine base, and na salt: catalytic activation of acetonitrile as a nucleophile. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of the American Chemical Society

VOLUME: 126

Page Numbers: 13632-3

Journal Abbreviation: J. Am. Chem. Soc.

ISSN: 0002-7863

DAY: 27

MONTH: Oct

YEAR: 2004

Cooperative catalysis of a cationic ruthenium complex, amine base, and na salt: catalytic activation of acetonitrile as a nucleophile. Information

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LANGUAGE: eng

NlmUniqueID: 7503056

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Grant and Affiliation Information for Cooperative catalysis of a cationic ruthenium complex, amine base, and na salt: catalytic activation of acetonitrile as a nucleophile.

AFFILIATION: Graduate School of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

Country: United States

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MEDLINETA: J Am Chem Soc

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