Cooperation and conflict in microbial biofilms.

Cooperation and conflict in microbial biofilms. Research Abstract Details 

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Cooperation and conflict in microbial biofilms. Abstract Text:

Joao B Xavier,Kevin R Foster,

Biofilms, in which cells attach to surfaces and secrete slime (polymeric substances), are central to microbial life. Biofilms are often thought to require high levels of cooperation because extracellular polymeric substances are a shared resource produced by one cell that can be used by others. Here we examine this hypothesis by using a detailed individual-based simulation of a biofilm to investigate the outcome of evolutionary competitions between strains that differ in their level of polymer production. Our model includes a biochemical description of the carbon fluxes for growth and polymer production, and it explicitly calculates diffusion-reaction effects and the resulting solute gradients in the biofilm. An emergent property of these simple but realistic mechanistic assumptions is a strong evolutionary advantage to extracellular polymer production. Polymer secretion is altruistic to cells above a focal cell: it pushes later generations in their lineage up and out into better oxygen conditions, but it harms others; polymer production suffocates neighboring nonpolymer producers. This property, analogous to vertical growth in plants, suggests that polymer secretion provides a strong competitive advantage to cell lineages within mixed-genotype biofilms: global cooperation is not required. Our model fundamentally changes how biofilms are expected to respond to changing social conditions; the presence of multiple strains in a biofilm should promote rather than inhibit polymer secretion.

Cooperation and conflict in microbial biofilms. Publishing Authors By Initials

JB Xavier,KR Foster,

For similar genetic phenomena: variation (genetics): mutation research abstracts see: genetic phenomena: variation (genetics): mutation research

PUBMED ID PMID:

MEDLINE DATE:

Cooperation and conflict in microbial biofilms. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Proceedings of the National Academy of Sciences of

VOLUME: 104

Page Numbers: 876-81

Journal Abbreviation: Proc. Natl. Acad. Sci. U.S.A.

ISSN: 0027-8424

DAY: 8

MONTH: 01

YEAR: 2007

Cooperation and conflict in microbial biofilms. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7505876

Cooperation and conflict in microbial biofilms. Keywords Mesh Terms:

KEYWORDS: Mutation

MESH TERMS: genetics

Chemical & Substance for Abstract: Cooperation and conflict in microbial biofilms. Information

Substance Name: Biopolymers

Registry Number: 0

Grant and Affiliation Information for Cooperation and conflict in microbial biofilms.

AFFILIATION: Center for Systems Biology, Harvard University, Bauer Laboratory, 7 Divinity Avenue, Cambridge, MA 02138, USA.

Country: United States

AGENCY: United States NIGMS

GRANT: 5P50 GM 068763-01

ACRONYM: GM

MEDLINETA: Proc Natl Acad Sci U S A

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