Conventional dendritic cells regulate the outcome of colonic inflammation independently of T cells.

Conventional dendritic cells regulate the outcome of colonic inflammation independently of T cells. Research Abstract Details 

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Conventional dendritic cells regulate the outcome of colonic inflammation independently of T cells. Abstract Text:

Kazumichi Abe,Kim Phung Nguyen,Sean D Fine,Ji-Hun Mo,Carol Shen,Steve Shenouda,Maripat Corr,Steffen Jung,Jongdae Lee,Lars Eckmann,Eyal Raz,

We explored the physiological role of conventional dendritic cells (cDCs) in acute colitis induced by a single cycle of dextran sodium sulfate administration. Depending on their mode of activation and independently of T cells, cDCs can enhance or attenuate the severity of dextran sodium sulfate-induced colitis. The latter beneficial effect was achieved, in part, by IFN-1 induced by Toll-like receptor 9-activated cDCs. IFN-1 inhibits colonic inflammation by regulating neutrophil and monocyte trafficking to the inflamed colon and restraining the inflammatory products of tissue macrophages. These data highlight a novel role of cDCs in the regulation of other innate immune cells and position them as major players in acute colonic inflammation.

Conventional dendritic cells regulate the outcome of colonic inflammation independently of T cells. Publishing Authors By Initials

K Abe,KP Nguyen,SD Fine,JH Mo,C Shen,S Shenouda,M Corr,S Jung,J Lee,L Eckmann,E Raz,

For similar diagnosis: prognosis: treatment outcome research abstracts see: diagnosis: prognosis: treatment outcome research

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Conventional dendritic cells regulate the outcome of colonic inflammation independently of T cells. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Proceedings of the National Academy of Sciences of

VOLUME: 104

Page Numbers: 17022-7

Journal Abbreviation: Proc. Natl. Acad. Sci. U.S.A.

ISSN: 0027-8424

DAY: 17

MONTH: 10

YEAR: 2007

Conventional dendritic cells regulate the outcome of colonic inflammation independently of T cells. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7505876

Conventional dendritic cells regulate the outcome of colonic inflammation independently of T cells. Keywords Mesh Terms:

KEYWORDS: Treatment Outcome

MESH TERMS: metabolism

Chemical & Substance for Abstract: Conventional dendritic cells regulate the outcome of colonic inflammation independently of T cells. Information

Substance Name: Dextran Sulfate

Registry Number: 9042-14-2

Grant and Affiliation Information for Conventional dendritic cells regulate the outcome of colonic inflammation independently of T cells.

AFFILIATION: Department of Medicine, University of California at San Diego, La Jolla, CA 92093, USA.

Country: United States

AGENCY: United States NIDDK

GRANT: DK 35108

ACRONYM: DK

MEDLINETA: Proc Natl Acad Sci U S A

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