A novel and convenient one-pot synthesis of multisubstituted pyrimidine analogues via multicomponent reactions is disclosed. This catalyst-free domino reaction proceeded smoothly in good to excellent yields and offered several other advantages including short reaction time, a simple experimental workup procedure, and no toxic byproduct. In addition, the obtained products in our experiments are interesting nitrogen heterocyclic molecules containing alpha- and beta-amino acid blocks.
Convenient one-pot synthesis of multisubstituted tetrahydropyrimidines via catalyst-free multicomponent reactions. Publishing Authors By Initials
Convenient one-pot synthesis of multisubstituted tetrahydropyrimidines via catalyst-free multicomponent reactions. Journal Published:
PUBLICATION TYPE: Research Support, Non-U.S. Gov
Journal: Organic letters
VOLUME: 9
Page Numbers: 4111-3
Journal Abbreviation: Org. Lett.
ISSN: 1523-7060
DAY: 22
MONTH: 09
YEAR: 2007
Convenient one-pot synthesis of multisubstituted tetrahydropyrimidines via catalyst-free multicomponent reactions. Information
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LANGUAGE: eng
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Grant and Affiliation Information for Convenient one-pot synthesis of multisubstituted tetrahydropyrimidines via catalyst-free multicomponent reactions.
AFFILIATION: The College of Chemistry, South China University of Technology, Guangzhou 510640, PRC.
Country: United States
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MEDLINETA: Org Lett
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