Controversies of aromatase localization in human breast cancer--stromal versus parenchymal cells.

Controversies of aromatase localization in human breast cancer--stromal versus parenchymal cells. Research Abstract Details 

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Controversies of aromatase localization in human breast cancer--stromal versus parenchymal cells. Abstract Text:

Yasuhiro Miki,Takashi Suzuki,Hironobu Sasano,

Aromatase is a key enzyme of estrogen production through conversion from serum androgens in estrogen-dependent postmenopausal breast cancer. Aromatase has been reported to be predominantly located in intratumoral stromal cells and adipocytes but not in parenchymal or carcinoma cells in breast cancer tissue. It is, however, true that there have been controversies regarding intratumoral localization of aromatase in human breast carcinoma, especially whether intratumoral production of estrogens through aromatase occurs in parenchymal or stromal cells. Results of several studies suggested that aromatase present in parenchymal carcinoma cells plays more important roles in the growth and invasion of breast carcinomas than that in stromal cells through providing higher levels of estrogens to carcinoma cells. Aromatase inhibitors are increasingly being used in place of tamoxifen after results of various clinical trials demonstrated that aromatase inhibitors are more effective in increasing survival and recurrence of estrogen-dependent breast cancer patients. Therefore, it is important to clarify the estrogen supplying pathway by aromatase inside of breast carcinoma tissues in order to evaluate the possible efficacy of aromatase inhibitor treatment. In this review, the controversies regarding these intratumoral localization patterns in human breast carcinoma will be briefly summarized.

Controversies of aromatase localization in human breast cancer--stromal versus parenchymal cells. Publishing Authors By Initials

Y Miki,T Suzuki,H Sasano,

For similar cells: connective tissue cells: stromal cells research abstracts see: cells: connective tissue cells: stromal cells research

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Controversies of aromatase localization in human breast cancer--stromal versus parenchymal cells. Journal Published:

PUBLICATION TYPE: Review

Journal: The Journal of steroid biochemistry and molecular

VOLUME: 106

Page Numbers: 97-101

Journal Abbreviation: J. Steroid Biochem. Mol. Biol.

ISSN: 0960-0760

DAY: 24

MONTH: 05

YEAR: 2007

Controversies of aromatase localization in human breast cancer--stromal versus parenchymal cells. Information

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LANGUAGE: eng

NlmUniqueID: 9015483

Controversies of aromatase localization in human breast cancer--stromal versus parenchymal cells. Keywords Mesh Terms:

KEYWORDS: Stromal Cells

MESH TERMS: metabolism

Chemical & Substance for Abstract: Controversies of aromatase localization in human breast cancer--stromal versus parenchymal cells. Information

Substance Name: Aromatase

Registry Number: EC 1.14.14.1

Grant and Affiliation Information for Controversies of aromatase localization in human breast cancer--stromal versus parenchymal cells.

AFFILIATION: Department of Pathology, Tohoku University Graduate School of Medicine, 2-1 Seiryo-machi, Aoba-ku, Sendai, Miyagi-ken 980-8575, Japan.

Country: England

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MEDLINETA: J Steroid Biochem Mol Biol

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