Control of electrical alternans in simulations of paced myocardium using extended time-delay autosynchronization.

Control of electrical alternans in simulations of paced myocardium using extended time-delay autosynchronization. Research Abstract Details 

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Control of electrical alternans in simulations of paced myocardium using extended time-delay autosynchronization. Abstract Text:

Carolyn M Berger,John W Cain,Joshua E S Socolar,Daniel J Gauthier,Carolyn M Berger,John W Cain,Joshua E S Socolar,Daniel J Gauthier,Carolyn M Berger,John W Cain,Joshua E S Socolar,Daniel J Gauthier,

Experimental studies have linked alternans, an abnormal beat-to-beat alternation of cardiac action potential duration, to the genesis of lethal arrhythmias such as ventricular fibrillation. Prior studies have considered various closed-loop feedback control algorithms for perturbing interstimulus intervals in such a way that alternans is suppressed. However, some experimental cases are restricted in that the controller's stimuli must preempt those of the existing waves that are propagating in the tissue, and therefore only shortening perturbations to the underlying pacing are allowed. We present results demonstrating that a technique known as extended time-delay autosynchronization (ETDAS) can effectively control alternans locally while operating within the above constraints. We show that ETDAS, which has already been used to control chaos in physical systems, has numerous advantages over previously proposed alternans control schemes.

Control of electrical alternans in simulations of paced myocardium using extended time-delay autosynchronization. Publishing Authors By Initials

CM Berger,JW Cain,JE Socolar,DJ Gauthier,CM Berger,JW Cain,JE Socolar,DJ Gauthier,CM Berger,JW Cain,JE Socolar,DJ Gauthier,

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Control of electrical alternans in simulations of paced myocardium using extended time-delay autosynchronization. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Physical review. E, Statistical, nonlinear, and so

VOLUME: 76

Page Numbers: 041917

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ISSN: 1539-3755

DAY: 25

MONTH: 10

YEAR: 2007

Control of electrical alternans in simulations of paced myocardium using extended time-delay autosynchronization. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Control of electrical alternans in simulations of paced myocardium using extended time-delay autosynchronization.

AFFILIATION: Department of Physics, Duke University, Durham, North Carolina 27708, USA and Center for Nonlinear and Complex Systems, Duke University, Durham, North Carolina 27708, USA.

Country: United States

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MEDLINETA: Phys Rev E Stat Nonlin Soft Ma

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