Control of daughter centriole formation by the pericentriolar material.

Control of daughter centriole formation by the pericentriolar material. Research Abstract Details 

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Control of daughter centriole formation by the pericentriolar material. Abstract Text:

Jadranka Loncarek,Polla Hergert,Valentin Magidson,Alexey Khodjakov,

Controlling the number of its centrioles is vital for the cell, as supernumerary centrioles cause multipolar mitosis and genomic instability. Normally, one daughter centriole forms on each mature (mother) centriole; however, a mother centriole can produce multiple daughters within a single cell cycle. The mechanisms that prevent centriole 'overduplication' are poorly understood. Here we use laser microsurgery to test the hypothesis that attachment of the daughter centriole to the wall of the mother inhibits formation of additional daughters. We show that physical removal of the daughter induces reduplication of the mother in S-phase-arrested cells. Under conditions when multiple daughters form simultaneously on a single mother, all of these daughters must be removed to induce reduplication. The number of daughter centrioles that form during reduplication does not always match the number of ablated daughter centrioles. We also find that exaggeration of the pericentriolar material (PCM) by overexpression of the PCM protein pericentrin in S-phase-arrested CHO cells induces formation of numerous daughter centrioles. We propose that that the size of the PCM cloud associated with the mother centriole restricts the number of daughters that can form simultaneously.

Control of daughter centriole formation by the pericentriolar material. Publishing Authors By Initials

J Loncarek,P Hergert,V Magidson,A Khodjakov,

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Control of daughter centriole formation by the pericentriolar material. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Nature cell biology

VOLUME: 10

Page Numbers: 322-8

Journal Abbreviation: Nat. Cell Biol.

ISSN: 1465-7392

DAY: 24

MONTH: 02

YEAR: 2008

Control of daughter centriole formation by the pericentriolar material. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Control of daughter centriole formation by the pericentriolar material.

AFFILIATION: Division of Molecular Medicine, Wadsworth Center, Albany, New York State Department of Health, Albany, New York 12201-0509, USA.

Country: England

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MEDLINETA: Nat Cell Biol

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