Control of compartment size by an EGF ligand from neighboring cells.

Control of compartment size by an EGF ligand from neighboring cells. Research Abstract Details 

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Control of compartment size by an EGF ligand from neighboring cells. Abstract Text:

Joseph Parker,

Insect bodies are subdivided into anterior (A) and posterior (P) compartments: cohesive fields of distinct cell lineage and cell affinity . Like organs in many animal species, compartments can develop to normal sizes despite considerable variation in cell division . This implies that overall compartment dimensions are subject to genetic control, but the mechanisms are unknown. Here, studying Drosophila's embryonic segments, I show that P compartment dimensions depend on epidermal growth factor receptor (EGFR) signaling. I suggest the primary activating ligand is Spitz, emanating from neighboring A compartment cells. Spi/EGFR activity stimulates P compartment cell enlargement and survival, but evidence is presented that Spitz is secreted in limited amounts, so that increasing the number of cells within the P compartment causes the per-cell Spitz level to drop. This leads to compensatory apoptosis and cell-size reductions that preserve compartment dimensions. Conversely, I propose that lowering P compartment cell numbers enhances per-cell Spitz availability; this increases cell survival and cell size, again safeguarding compartment size. The results argue that the gauging of P compartment size is due, at least in part, to cells surviving and growing according to Spi availability. These data offer mechanistic insight into how diffusible molecules control organ size.

Control of compartment size by an EGF ligand from neighboring cells. Publishing Authors By Initials

J Parker,

For similar biological phenomena, cell phenomena, and immunity: cell physiology: cell communication: signal transduction research abstracts see: biological phenomena, cell phenomena, and immunity: cell physiology: cell communication: signal transduction research

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MEDLINE DATE:

Control of compartment size by an EGF ligand from neighboring cells. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Current biology : CB

VOLUME: 16

Page Numbers: 2058-65

Journal Abbreviation: Curr. Biol.

ISSN: 0960-9822

DAY: 24

MONTH: Oct

YEAR: 2006

Control of compartment size by an EGF ligand from neighboring cells. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9107782

Control of compartment size by an EGF ligand from neighboring cells. Keywords Mesh Terms:

KEYWORDS: Signal Transduction

MESH TERMS: physiology

Chemical & Substance for Abstract: Control of compartment size by an EGF ligand from neighboring cells. Information

Substance Name: Receptor, Epidermal Growth Factor

Registry Number: EC 2.7.1.112

Grant and Affiliation Information for Control of compartment size by an EGF ligand from neighboring cells.

AFFILIATION: Division of Cell Biology, Medical Research Council Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, United Kingdom. jp2488@columbia.edu

Country: England

AGENCY: United States NICHD

GRANT: HD42770

ACRONYM: HD

MEDLINETA: Curr Biol

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