Control of a multisubunit DNA motor by a thermoresponsive polymer switch.

Control of a multisubunit DNA motor by a thermoresponsive polymer switch. Research Abstract Details 

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Control of a multisubunit DNA motor by a thermoresponsive polymer switch. Abstract Text:

Sivanand S Pennadam,Matthieu D Lavigne,Christina F Dutta,Keith Firman,Darren Mernagh,Dariusz C ,Cameron Alexander,

The conjugation of thermoresponsive polymers to multisubunit, multifunctional hybrid type 1 DNA restriction-modification (R-M) enzymes enables temperature-controlled "switching" of DNA methylation by the conjugate. Polymers attached to the enzyme at a subunit distal to the methylation subunit allow retention of DNA recognition and ATPase activity while controlling methylation of plasmid DNA. This regulation of enzyme activity arises from the coil-globule phase transitions of the polymer as shown in light scattering and gel retardation assays.

Control of a multisubunit DNA motor by a thermoresponsive polymer switch. Publishing Authors By Initials

SS Pennadam,MD Lavigne,CF Dutta,K Firman,D Mernagh,DC ,C Alexander,

For similar proteins: protein subunits research abstracts see: proteins: protein subunits research

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Control of a multisubunit DNA motor by a thermoresponsive polymer switch. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of the American Chemical Society

VOLUME: 126

Page Numbers: 13208-9

Journal Abbreviation: J. Am. Chem. Soc.

ISSN: 0002-7863

DAY: 20

MONTH: Oct

YEAR: 2004

Control of a multisubunit DNA motor by a thermoresponsive polymer switch. Information

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LANGUAGE: eng

NlmUniqueID: 7503056

Control of a multisubunit DNA motor by a thermoresponsive polymer switch. Keywords Mesh Terms:

KEYWORDS: Protein Subunits

MESH TERMS: chemistry

Chemical & Substance for Abstract: Control of a multisubunit DNA motor by a thermoresponsive polymer switch. Information

Substance Name: Deoxyribonucleases, Type I Site-Specific

Registry Number: EC 3.1.21.3

Grant and Affiliation Information for Control of a multisubunit DNA motor by a thermoresponsive polymer switch.

AFFILIATION: School of Pharmacy and Biomedical Sciences, Institute of Biomedical and Biomolecular Sciences, University of Portsmouth, Portsmouth PO1 2DT, United Kingdom.

Country: United States

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MEDLINETA: J Am Chem Soc

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