Continuous and intermittent exposure to ethanol: effect on NG 108-15 cell membrane phospholipids.

Continuous and intermittent exposure to ethanol: effect on NG 108-15 cell membrane phospholipids. Research Abstract Details 

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Continuous and intermittent exposure to ethanol: effect on NG 108-15 cell membrane phospholipids. Abstract Text:

The effect of continuous and intermittent ethanol exposure on the phospholipid composition of Neuroblastoma x Glioma (NG 108-15) cell membranes was investigated. The cells were treated with ethanol for three weeks. Continuous ethanol exposure (150 mM) produced an increase (27%) in the amount of phosphatidylcholine, whereas intermittent ethanol treatment (150 mM) induced a 22% reduction of this lipid. Decreases of phosphatidylethanolamine plasmalogen (8.5%), phosphatidylinositol (16%) and phosphatidylserine (24%) were also seen after intermittent exposure. After binge administration, the concentration of total phospholipids was reduced by 17%, whereas continuous exposure produced a 19% increase. Both intermittent and continuous exposure induced a reduction in the total protein content. No changes in phosphatidic acid, sphingomyelin, phosphatidylcholine plasmalogen or phosphatidylethanolamine (diacyl form) were detected with either treatment. The importance of this study is that ethanol, irrespective of amount, can elicit different effects depending on the pattern of administration.

Continuous and intermittent exposure to ethanol: effect on NG 108-15 cell membrane phospholipids. Publishing Authors By Initials

For similar cells: cells, cultured: tumor cells, cultured research abstracts see: cells: cells, cultured: tumor cells, cultured research

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Continuous and intermittent exposure to ethanol: effect on NG 108-15 cell membrane phospholipids. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Alcohol and alcoholism (Oxford, Oxfordshire). Supp

VOLUME: 1

Page Numbers: 227-31

Journal Abbreviation:

ISSN: 1358-6173

DAY: 26

MONTH: 02

YEAR: 1991

Continuous and intermittent exposure to ethanol: effect on NG 108-15 cell membrane phospholipids. Information

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LANGUAGE: eng

NlmUniqueID: 8804836

Continuous and intermittent exposure to ethanol: effect on NG 108-15 cell membrane phospholipids. Keywords Mesh Terms:

KEYWORDS: Tumor Cells, Cultured

MESH TERMS: metabolism

Chemical & Substance for Abstract: Continuous and intermittent exposure to ethanol: effect on NG 108-15 cell membrane phospholipids. Information

Substance Name: Ethanol

Registry Number: 64-17-5

Grant and Affiliation Information for Continuous and intermittent exposure to ethanol: effect on NG 108-15 cell membrane phospholipids.

AFFILIATION: Department of Psychiatry and Neurochemistry, University of Lund, Sweden.

Country: ENGLAND

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MEDLINETA: Alcohol Alcohol Suppl

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