Continued divergence in VO2max of rats artificially selected for running endurance is mediated by greater convective blood O2 delivery.

Continued divergence in VO2max of rats artificially selected for running endurance is mediated by greater convective blood O2 delivery. Research Abstract Details 

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Continued divergence in VO2max of rats artificially selected for running endurance is mediated by greater convective blood O2 delivery. Abstract Text:

We previously showed that after seven generations of artificial selection of rats for running capacity, maximal O2 uptake (VO2max) was 12% greater in high-capacity (HCR) than in low-capacity runners (LCR). This difference was due exclusively to a greater O2 uptake and utilization by skeletal muscle of HCR, without differences between lines in convective O2 delivery to muscle by the cardiopulmonary system (QO2max). The present study in generation 15 (G15) female rats tested the hypothesis that continuing improvement in skeletal muscle O2 transfer must be accompanied by augmentation in QO2max to support VO2max of HCR. Systemic O2 transport was studied during maximal normoxic and hypoxic exercise (inspired PO2 approximately 70 Torr). VO2max divergence between lines increased because of both improvement in HCR and deterioration in LCR: normoxic VO2max was 50% higher in HCR than LCR. The greater VO2max in HCR was accompanied by a 41% increase in QO2max: 96.1 +/- 4.0 in HCR vs. 68.1 +/- 2.5 ml stpd O2 x min(-1) x kg(-1) in LCR (P < 0.01) during normoxia. The greater G15 QO2max of HCR was due to a 48% greater stroke volume than LCR. Although tissue O2 diffusive conductance continued to increase in HCR, tissue O2 extraction was not significantly different from LCR at G15, because of the offsetting effect of greater HCR blood flow on tissue O2 extraction. These results indicate that continuing divergence in VO2max between lines occurs largely as a consequence of changes in the capacity to deliver O2 to the exercising muscle.

Continued divergence in VO2max of rats artificially selected for running endurance is mediated by greater convective blood O2 delivery. Publishing Authors By Initials

For similar genetic processes: selection (genetics) research abstracts see: genetic processes: selection (genetics) research

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Continued divergence in VO2max of rats artificially selected for running endurance is mediated by greater convective blood O2 delivery. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of applied physiology (Bethesda, Md. : 198

VOLUME: 101

Page Numbers: 1288-96

Journal Abbreviation: J. Appl. Physiol.

ISSN: 8750-7587

DAY: 15

MONTH: 06

YEAR: 2006

Continued divergence in VO2max of rats artificially selected for running endurance is mediated by greater convective blood O2 delivery. Information

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LANGUAGE: eng

NlmUniqueID: 8502536

Continued divergence in VO2max of rats artificially selected for running endurance is mediated by greater convective blood O2 delivery. Keywords Mesh Terms:

KEYWORDS: Selection (Genetics)

MESH TERMS: physiology

Chemical & Substance for Abstract: Continued divergence in VO2max of rats artificially selected for running endurance is mediated by greater convective blood O2 delivery. Information

Substance Name: Oxygen

Registry Number: 7782-44-7

Grant and Affiliation Information for Continued divergence in VO2max of rats artificially selected for running endurance is mediated by greater convective blood O2 delivery.

AFFILIATION: Department of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, KS 66160, USA. ngonzale@kumc.edu

Country: United States

AGENCY: United States NCRR

GRANT: RR-17718

ACRONYM: RR

MEDLINETA: J Appl Physiol

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