Context-sensitive data integration and prediction of biological networks.

Context-sensitive data integration and prediction of biological networks. Research Abstract Details 

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Context-sensitive data integration and prediction of biological networks. Abstract Text:

Chad L Myers,Olga G Troyanskaya,

MOTIVATION: Several recent methods have addressed the problem of heterogeneous data integration and network prediction by modeling the noise inherent in high-throughput genomic datasets, which can dramatically improve specificity and sensitivity and allow the robust integration of datasets with heterogeneous properties. However, experimental technologies capture different biological processes with varying degrees of success, and thus, each source of genomic data can vary in relevance depending on the biological process one is interested in predicting. Accounting for this variation can significantly improve network prediction, but to our knowledge, no previous approaches have explicitly leveraged this critical information about biological context. RESULTS: We confirm the presence of context-dependent variation in functional genomic data and propose a Bayesian approach for context-sensitive integration and query-based recovery of biological process-specific networks. By applying this method to Saccharomyces cerevisiae, we demonstrate that leveraging contextual information can significantly improve the precision of network predictions, including assignment for uncharacterized genes. We expect that this general context-sensitive approach can be applied to other organisms and prediction scenarios. AVAILABILITY: A software implementation of our approach is available on request from the authors. SUPPLEMENTARY INFORMATION: Supplementary data are available at http://avis.princeton.edu/contextPIXIE/

Context-sensitive data integration and prediction of biological networks. Publishing Authors By Initials

CL Myers,OG Troyanskaya,

For similar natural sciences: science: systems integration research abstracts see: natural sciences: science: systems integration research

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Context-sensitive data integration and prediction of biological networks. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Bioinformatics (Oxford, England)

VOLUME: 23

Page Numbers: 2322-30

Journal Abbreviation: Bioinformatics

ISSN: 1460-2059

DAY: 28

MONTH: 06

YEAR: 2007

Context-sensitive data integration and prediction of biological networks. Information

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LANGUAGE: eng

NlmUniqueID: 9808944

Context-sensitive data integration and prediction of biological networks. Keywords Mesh Terms:

KEYWORDS: Systems Integration

MESH TERMS: physiology

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Substance Name: Proteome

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Grant and Affiliation Information for Context-sensitive data integration and prediction of biological networks.

AFFILIATION: Department of Computer Science, Princeton University, 35 Olden Street, Princeton, NJ, USA.

Country: England

AGENCY: United States NHGRI

GRANT: T32 HG003284

ACRONYM: HG

MEDLINETA: Bioinformatics

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