Context-dependent regulation of Hox protein functions by CK2 phosphorylation sites.

Context-dependent regulation of Hox protein functions by CK2 phosphorylation sites. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Context-dependent regulation of Hox protein functions by CK2 phosphorylation sites. Abstract Text:

Variations in Hox protein sequences and functions have been proposed to contribute to evolutionary changes in appendage shape and number in crustaceans and insects. One model is that insect Hox proteins of the Ultrabithorax (UBX) ortholog class evolved increased abilities to repress Distal-less (Dll) transcription and appendage development in part through the loss of serine and threonine residues in casein kinase 2 (CK2) phosphorylation sites. To explore this possibility, we constructed and tested the appendage repression function of chimeric proteins with insertions of different CK2 consensus sites or phosphomimetics of CK2 sites in C-terminal regions of Drosophila melanogaster UBX. Our results indicate that CK2 sites C-terminal to the homeodomain can inhibit the appendage repression functions of UBX proteins, but only in the context of specific amino acid sequences. Our results, combined with previous findings on evolutionary changes in Hox protein, suggest how intra-protein regulatory changes can diversify Hox protein function, and thus animal morphology.

Context-dependent regulation of Hox protein functions by CK2 phosphorylation sites. Publishing Authors By Initials

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Context-dependent regulation of Hox protein functions by CK2 phosphorylation sites. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Development genes and evolution

VOLUME: 218

Page Numbers: 321-32

Journal Abbreviation: Dev. Genes Evol.

ISSN: 0949-944X

DAY: 27

MONTH: 05

YEAR: 2008

Context-dependent regulation of Hox protein functions by CK2 phosphorylation sites. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9613264

Context-dependent regulation of Hox protein functions by CK2 phosphorylation sites. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Context-dependent regulation of Hox protein functions by CK2 phosphorylation sites. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Context-dependent regulation of Hox protein functions by CK2 phosphorylation sites.

AFFILIATION: Neuroscience & Aging Research Center, The Burnham Institute for Medical Research, 10901 North Torrey Pines Rd, La Jolla, CA, 92037, USA.

Country: Germany

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Dev Genes Evol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Context-dependent regulation of Hox protein functions by CK2 phosphorylation sites Related Publications

• Anabolic androgenic steroids and aggression: studies using animal models.
• Antp-type homeodomains have distinct DNA binding specificities that correlate with their different regulatory functions in embryos.
• Behavioral effects of pubertal anabolic androgenic steroid exposure in male rats with low serotonin.
• Canine esophageal motor function: effects of arterial and intravenous vasopressin.
• Combined rapid-steam hydrolysis and organosolv pretreatment of mixed southern hardwoods.
• Context-dependent regulation of Hox protein functions by CK2 phosphorylation sites.
• Cystine and methionine metabolism by chicks receiving raw or autoclaved soybean oil meal.
• Factors influencing aggression toward females by male rats exposed to anabolic androgenic steroids during puberty.
• Genome-wide analyses of alternative splicing in plants: Opportunities and challenges.
• Hox genes differentially regulate Serrate to generate segment-specific structures.
• In their own words: serving as an ACS delegate to the AMA.
• Interaction of glyceraldehyde-3-phosphate dehydrogenase in the light-induced rod alpha-transducin translocation.
• Intubation of an infant with Pierre Robin sequence under dexmedetomidine sedation using the Shikani Optical Stylet.
• Light threshold-controlled cone alpha-transducin translocation.
• Mapping functional specificity in the Dfd and Ubx homeo domains.
• Metastatic Hurthle cell carcinoma and medical certification.
• Nanoceria particles prevent ROI-induced blindness.
• Prepubertal social subjugation and anabolic androgenic steroid-induced aggression in male rats.
• Primary spindle-cell sarcoma in a Meckel's diverticulum.
• Pubertal exposure to anabolic androgenic steroids increases spine densities on neurons in the limbic system of male rats.
• Quality assurance strategies for home-delivered long term care.
• Rare earth nanoparticles prevent retinal degeneration induced by intracellular peroxides.
• Recurrent allergic fungal sinusitis sequentially caused by Exserohilum and Bipolaris.
• Regulating the expression and function of homeotic genes.
• Talk to you tomorrow. Interview by Raphael M Barishansky.
• The future of emergency medical services communications systems: time for a change.
• The impact of epidemic influenza, Canada, 1918-1919.
• The impact of epidemic influenza: Canada, 1918-1919.