Content of Polyphenolic Compounds in the Nigerian Stimulants Cola nitida ssp. alba, Cola nitida ssp. rubra A. Chev, and Cola acuminata Schott & Endl and Their Antioxidant Capacity.

Content of Polyphenolic Compounds in the Nigerian Stimulants Cola nitida ssp. alba, Cola nitida ssp. rubra A. Chev, and Cola acuminata Schott & Endl and Their Antioxidant Capacity. Research Abstract Details 

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Content of Polyphenolic Compounds in the Nigerian Stimulants Cola nitida ssp. alba, Cola nitida ssp. rubra A. Chev, and Cola acuminata Schott & Endl and Their Antioxidant Capacity. Abstract Text:

Sunday Ene-Ojo Atawodi,Beate Pfundstein,Roswitha Haubner,Bertold Spiegelhalder,Helmut Bartsch,Robert Wyn Owen,Sunday Ene-Ojo Atawodi,Beate Pfundstein,Roswitha Haubner,Bertold Spiegelhalder,Helmut Bartsch,Robert Wyn Owen,Sunday Ene-Ojo Atawodi,Beate Pfundstein,Roswitha Haubner,Bertold Spiegelhalder,Helmut Bartsch,Robert Wyn Owen,

Varieties of kola nuts ( Cola nitida alba, Cola nitida rubra A. Chev, and Cola acuminata Schott & Endl), a group of popular Nigerian and West African stimulants, were analyzed for their content of secondary plant metabolites. The three varieties of the kola nuts contained appreciable levels of (+)-catechin (27-37 g/kg), caffeine (18-24 g/kg), (-)-epicatechin (20-21 g/kg), procyanidin B 1 [epicatechin-(4beta-->8)-catechin] (15-19 g/kg), and procyanidin B 2 [epicatechin-(4beta-->8)-epicatechin] (7-10 g/kg). Antioxidant capacity of the extracts and purified metabolites was assessed by two HPLC-based and two colorimetric in vitro assays. Extracts of all varieties exhibited antioxidant capacity with IC 50 values in the range 1.70-2.83 and 2.74-4.08 mg/mL in the hypoxanthine/xanthine oxidase and 2-deoxyguanosine HPLC-based assays, respectively. Utilization of HPLC-based assays designed to reflect in situ generation of free radicals (e.g., HO (*)), as opposed to general assays (DPPH, FRAP) in common use which do not, indicate that, of the major secondary plant metabolites present in kola nut extracts, caffeine is potentially the more effective cancer chemopreventive metabolite in terms of its antioxidant capacity.

Content of Polyphenolic Compounds in the Nigerian Stimulants Cola nitida ssp. alba, Cola nitida ssp. rubra A. Chev, and Cola acuminata Schott & Endl and Their Antioxidant Capacity. Publishing Authors By Initials

SE Atawodi,B Pfundstein,R Haubner,B Spiegelhalder,H Bartsch,RW Owen,SE Atawodi,B Pfundstein,R Haubner,B Spiegelhalder,H Bartsch,RW Owen,SE Atawodi,B Pfundstein,R Haubner,B Spiegelhalder,H Bartsch,RW Owen,

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Content of Polyphenolic Compounds in the Nigerian Stimulants Cola nitida ssp. alba, Cola nitida ssp. rubra A. Chev, and Cola acuminata Schott & Endl and Their Antioxidant Capacity. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of agricultural and food chemistry

VOLUME: 55

Page Numbers: 9824-8

Journal Abbreviation: J. Agric. Food Chem.

ISSN: 0021-8561

DAY: 3

MONTH: 11

YEAR: 2007

Content of Polyphenolic Compounds in the Nigerian Stimulants Cola nitida ssp. alba, Cola nitida ssp. rubra A. Chev, and Cola acuminata Schott & Endl and Their Antioxidant Capacity. Information

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LANGUAGE: eng

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AFFILIATION: r.owen@dkfz-heidelberg.de.

Country: United States

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MEDLINETA: J Agric Food Chem

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