Contact sensitivity in patients with venous leg ulcers in Serbia: comparison with contact dermatitis patients and relationship to ulcer duration.

Contact sensitivity in patients with venous leg ulcers in Serbia: comparison with contact dermatitis patients and relationship to ulcer duration. Research Abstract Details 

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Contact sensitivity in patients with venous leg ulcers in Serbia: comparison with contact dermatitis patients and relationship to ulcer duration. Abstract Text:

Jasmina Janki?evi?,Sonja Vesi?,Jelica Vuki?evi?,Miodrag Gaji?,Metka Adamic,Milos D Pavlovi?,Jasmina Janki?evi?,Sonja Vesi?,Jelica Vuki?evi?,Miodrag Gaji?,Metka Adamic,Milos D Pavlovi?,Jasmina Janki?evi?,Sonja Vesi?,Jelica Vuki?evi?,Miodrag Gaji?,Metka Adamic,Milos D Pavlovi?,

Background: Contact hypersensitivity is a common occurrence in patients with chronic venous leg ulcers (CVLU) with allergen profiles depending upon the local treatment policies. Objective: This study was to determine the frequency of contact sensitivity, prevalence of individual allergens, polyvalent sensitization, and/or their relationship to ulcers duration in the population of CVLU and contact dermatitis patients in Serbia. Patients: 75 patients with CVLU and 82 patients with clinically suspected contact dermatitis were prospectively included in the study. The patients were patch tested with a series of 21 standard and 22 supplemental allergens. Results: 73% (n = 55) of CVLU and 52% (n = 43) of control subjects had 1 or more positive patch test results (P < 0.01). Polysensitization was found in 53% of patients and 21% of controls (P < 0.01). CVLU patients run 2.5 and 4.3 higher risk for contact sensitization and polysensitization, respectively. The most common allergens were Balsam of Peru (21.3%), carba mix (18.7%), fusidic acid (17.3%), colophony (13.3%), paraben mix (12%), chloramphenicol (12%), silver nitrate (12%), and neomycin (10.7%). Polivalent sensitization and higher mean number of allergens were associated with ulcer duration >5 years. Conclusions: The results confirm a high rate of contact (poly)sensitization in patients with CVLU and local variability in allergen prevalence.

Contact sensitivity in patients with venous leg ulcers in Serbia: comparison with contact dermatitis patients and relationship to ulcer duration. Publishing Authors By Initials

J Janki?evi?,S Vesi?,J Vuki?evi?,M Gaji?,M Adamic,MD Pavlovi?,J Janki?evi?,S Vesi?,J Vuki?evi?,M Gaji?,M Adamic,MD Pavlovi?,J Janki?evi?,S Vesi?,J Vuki?evi?,M Gaji?,M Adamic,MD Pavlovi?,

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Contact sensitivity in patients with venous leg ulcers in Serbia: comparison with contact dermatitis patients and relationship to ulcer duration. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Contact dermatitis

VOLUME: 58

Page Numbers: 32-6

Journal Abbreviation: Contact Derm.

ISSN: 0105-1873

DAY: 24

MONTH: Jan

YEAR: 2008

Contact sensitivity in patients with venous leg ulcers in Serbia: comparison with contact dermatitis patients and relationship to ulcer duration. Information

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LANGUAGE: eng

NlmUniqueID: 7604950

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Grant and Affiliation Information for Contact sensitivity in patients with venous leg ulcers in Serbia: comparison with contact dermatitis patients and relationship to ulcer duration.

AFFILIATION: Institute of Dermatovenereology, Clinical Center of Serbia, Pasterova 2, 1100 Belgrade, Serbia.

Country: Denmark

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MEDLINETA: Contact Dermatitis

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