Constitutive expression of RbAp46 induces epithelial-mesenchymal transition in mammary epithelial cells.

Constitutive expression of RbAp46 induces epithelial-mesenchymal transition in mammary epithelial cells. Research Abstract Details 

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Constitutive expression of RbAp46 induces epithelial-mesenchymal transition in mammary epithelial cells. Abstract Text:

Guan-Cheng Li,Zhao-Yi Wang,

BACKGROUND: Epithelial-mesenchymal transition (EMT) is a component of several morphogenetic and organogenetic processes during embryonic development. EMT is a strictly regulated process and its aberrant regulation may contribute to cancer progression and metastasis. The retinoblastoma suppressor (Rb)-associated protein 46 (RbAp46) is a component of the histone-modifying and -remodeling complexes. MATERIALS AND METHODS: Western blot and immunofluorescent assays with epithelial and mesenchymal markers and cell migration and invasion assays were employed. RESULTS: Mammary epithelial cells, MCF10AT3B, that express recombinant RbAp46 exhibited an EMT associated with the down-regulation of epithelial markers and up-regulation of mesenchymal markers, as well as an increased migration and invasion phenotype. CONCLUSION: Rbap46 may be an important player in EMT during embryonic development. Dysregulated RbAp46 expression may contribute to cancer progression and metastasis.

Constitutive expression of RbAp46 induces epithelial-mesenchymal transition in mammary epithelial cells. Publishing Authors By Initials

GC Li,ZY Wang,

For similar proteins: dna-binding proteins: retinoblastoma protein research abstracts see: proteins: dna-binding proteins: retinoblastoma protein research

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Constitutive expression of RbAp46 induces epithelial-mesenchymal transition in mammary epithelial cells. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Anticancer research

VOLUME: 26

Page Numbers: 3555-60

Journal Abbreviation: Anticancer Res.

ISSN: 0250-7005

DAY: 3

MONTH: 12

YEAR: 2007

Constitutive expression of RbAp46 induces epithelial-mesenchymal transition in mammary epithelial cells. Information

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LANGUAGE: eng

NlmUniqueID: 8102988

Constitutive expression of RbAp46 induces epithelial-mesenchymal transition in mammary epithelial cells. Keywords Mesh Terms:

KEYWORDS: Retinoblastoma Protein

MESH TERMS: metabolism

Chemical & Substance for Abstract: Constitutive expression of RbAp46 induces epithelial-mesenchymal transition in mammary epithelial cells. Information

Substance Name: Retinoblastoma Protein

Registry Number: 0

Grant and Affiliation Information for Constitutive expression of RbAp46 induces epithelial-mesenchymal transition in mammary epithelial cells.

AFFILIATION: Zhuhai Campus, Zunyi Medical College, Zhuhai, Guangdong 519041, PR China.

Country: Greece

AGENCY: United States NCI

GRANT: R01 CA84328

ACRONYM: CA

MEDLINETA: Anticancer Res

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