Constituents of Brazilian red propolis and their preferential cytotoxic activity against human pancreatic PANC-1 cancer cell line in nutrient-deprived condition.

Constituents of Brazilian red propolis and their preferential cytotoxic activity against human pancreatic PANC-1 cancer cell line in nutrient-deprived condition. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Constituents of Brazilian red propolis and their preferential cytotoxic activity against human pancreatic PANC-1 cancer cell line in nutrient-deprived condition. Abstract Text:

Suresh Awale,Feng Li,Hiroko Onozuka,Hiroyasu Esumi,Yasuhiro Tezuka,Shigetoshi Kadota,Suresh Awale,Feng Li,Hiroko Onozuka,Hiroyasu Esumi,Yasuhiro Tezuka,Shigetoshi Kadota,Suresh Awale,Feng Li,Hiroko Onozuka,Hiroyasu Esumi,Yasuhiro Tezuka,Shigetoshi Kadota,

Human pancreatic cancer cells such as PANC-1 are known to exhibit marked tolerance to nutrition starvation that enables them to survive for prolonged period of time even under extremely nutrient-deprived conditions. Thus, elimination of this tolerance to nutrition starvation is regarded as a novel approach in anticancer drug development. In this study, the MeOH soluble extract of Brazilian red propolis was found to kill 100% PANC-1 cells preferentially in the nutrient-deprived condition at the concentration of 10mug/mL. Further phytochemical investigation led to the isolation of 43 compounds including three new compounds, (6aS,11aS)-6a-ethoxymedicarpan (1), 2-(2',4'-dihydroxyphenyl)-3-methyl-6-methoxybenzofuran (2), and 2,6-dihydroxy-2-[(4-hydroxyphenyl)methyl]-3-benzofuranone (3). Among them, (6aR,11aR)-3,8-dihydroxy-9-methoxypterocarpan (21, DMPC) displayed the most potent 100% preferential cytotoxicity (PC(100)) at the concentration of 12.5muM. Further study on the mode of cell death induced by DMPC against PANC-1 cells indicated that killing process was not accompanied by DNA fragmentation, rather through a nonapoptotic pathway accompanied by necrotic-type morphological changes.

Constituents of Brazilian red propolis and their preferential cytotoxic activity against human pancreatic PANC-1 cancer cell line in nutrient-deprived condition. Publishing Authors By Initials

S Awale,F Li,H Onozuka,H Esumi,Y Tezuka,S Kadota,S Awale,F Li,H Onozuka,H Esumi,Y Tezuka,S Kadota,S Awale,F Li,H Onozuka,H Esumi,Y Tezuka,S Kadota,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Constituents of Brazilian red propolis and their preferential cytotoxic activity against human pancreatic PANC-1 cancer cell line in nutrient-deprived condition. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Bioorganic & medicinal chemistry

VOLUME: 16

Page Numbers: 181-9

Journal Abbreviation: Bioorg. Med. Chem.

ISSN: 1464-3391

DAY: 5

MONTH: 10

YEAR: 2007

Constituents of Brazilian red propolis and their preferential cytotoxic activity against human pancreatic PANC-1 cancer cell line in nutrient-deprived condition. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9413298

Constituents of Brazilian red propolis and their preferential cytotoxic activity against human pancreatic PANC-1 cancer cell line in nutrient-deprived condition. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Constituents of Brazilian red propolis and their preferential cytotoxic activity against human pancreatic PANC-1 cancer cell line in nutrient-deprived condition. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Constituents of Brazilian red propolis and their preferential cytotoxic activity against human pancreatic PANC-1 cancer cell line in nutrient-deprived condition.

AFFILIATION: Institute of Natural Medicine, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan.

Country: England

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Bioorg Med Chem

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Constituents of Brazilian red propolis and their preferential cytotoxic activity against human pancreatic PANC-1 cancer cell line in nutrient-deprived condition Related Publications

• A fistula from the coronary artery into the right atrium caused by transseptal puncture.
• Adenosquamous carcinoma with cilium formation, mucin production and keratinization in the nasal cavity of a red fox (Vulpes vulpes schrencki).
• Autologous stem cell transplantation for refractory Langerhans' cell histiocytosis.
• Bioactive secondary metabolites from Boesenbergia pandurata of Myanmar and their preferential cytotoxicity against human pancreatic cancer PANC-1 cell line in nutrient-deprived medium.
• Comparison of sarpogrelate and ticlopidine in bare metal coronary stent implantation.
• Constituents of Brazilian red propolis and their preferential cytotoxic activity against human pancreatic PANC-1 cancer cell line in nutrient-deprived condition.
• Cytotoxic constituents from Brazilian red propolis and their structure-activity relationship.
• Epithelioid variant of pleomorphic liposarcoma in a heifer.
• Functional analyses of the Physcomitrella patens phytochromes in regulating chloroplast avoidance movement.
• Inhibitory Activity of the Ethyl Acetate Fraction from Viscum coloratum on Bone Resorption.
• Klippel-feil syndrome accompanied by pulmonary artery sling.
• New Diarylheptanoid from the Seeds of Alpinia blepharocalyx.
• New ST-segment elevation caused by spontaneous recanalization of the left anterior descending coronary artery.
• Novel anticancer agents, kayeassamins A and B from the flower of Kayea assamica of Myanmar.
• Novel anticancer agents, kayeassamins C-I from the flower of Kayea assamica of Myanmar.
• Panduratins D-I, Novel Secondary Metabolites from Rhizomes of Boesenbergia pandurata.
• Plasma HHV-6 viral load-guided preemptive therapy against HHV-6 encephalopathy after allogeneic stem cell transplantation: a prospective evaluation.
• Properties of protein kinases in brain coated vesicles.
• Relationship between the severity of obstructive sleep apnea and impaired glucose metabolism in patients with obstructive sleep apnea.
• Simultaneous immobilization of dehydrogenases on polyvinylidene difluoride resin after separation by non-denaturing two-dimensional electrophoresis.
• Sinus arrest caused by occlusion of the sinus node artery during percutaneous coronary intervention for lesions of the proximal right coronary artery.
• Successful removal of a giant skull base metastasis from hepatocellular carcinoma after direct ethanol injection: case report.
• The in vitro Anti-Osteoporotic Activity of some Diarylheptanoids and Lignans from the Rhizomes of Dioscorea spongiosa.
• [A case of Sweet's syndrome with a variety of chest radiological findings]
• [A case of toxocariasis showing migratory nodular shadows with halos]
• [Acceptance of newly graduating nurses. Education of newly graduated nurses and its follow-up]
• [Chronic hypersensitivity pneumonitis induced by Shiitake mushroom cultivation: case report and review of literature]
• [Pulmonary metastasis of fibrosarcomatous variant of dermatofibrosarcoma protuberans: case report and review of literature]