Constituents from the leaves of Nelumbo nucifera stimulate lipolysis in the white adipose tissue of mice.

Constituents from the leaves of Nelumbo nucifera stimulate lipolysis in the white adipose tissue of mice. Research Abstract Details 

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Constituents from the leaves of Nelumbo nucifera stimulate lipolysis in the white adipose tissue of mice. Abstract Text:

Emika Ohkoshi,Hiromi Miyazaki,Kazutoshi Shindo,Hiroyuki Watanabe,Aruto Yoshida,Hiroaki Yajima,Emika Ohkoshi,Hiromi Miyazaki,Kazutoshi Shindo,Hiroyuki Watanabe,Aruto Yoshida,Hiroaki Yajima,

Nelumbo nucifera Gaertn. (Nymphaceae) has been used for various medicinal purposes as in Chinese herbal medicine. In particular, the leaves are known for diuretic and astringent properties, and are used to treat obesity. During our search for a plant-derived anti-obesity agent from natural products, we have found that a 50% ethanol (EtOH) extract prepared from the leaves of N. nucifera (NN) stimulated lipolysis in the white adipose tissue (WAT) of mice and that the beta-adrenergic receptor (beta-AR) pathway was involved in this effect. In subsequent experiments, dietary supplementation of NN resulted in a significant suppression of body weight gain in A/J mice fed a high-fat diet. Bioassay-guided fractionation and repeated chromatography of NN has led to the isolation and identification of quercetin 3-O-alpha-arabinopyranosyl-(1-->2)-beta-galactopyranoside (1), rutin (2), (+)-catechin (3), hyperoside (4), isoquercitrin (5), quercetin (6) and astragalin (7). Of these, compounds 1, 3, 4, 5 and 7 exhibited lipolytic activity, especially in visceral adipose tissue. Our results indicate that the effects of NN in preventing diet-induced obesity appear to be due to various flavonoids and that the activation of beta-AR pathway was involved, at least in part.

Constituents from the leaves of Nelumbo nucifera stimulate lipolysis in the white adipose tissue of mice. Publishing Authors By Initials

E Ohkoshi,H Miyazaki,K Shindo,H Watanabe,A Yoshida,H Yajima,E Ohkoshi,H Miyazaki,K Shindo,H Watanabe,A Yoshida,H Yajima,

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Constituents from the leaves of Nelumbo nucifera stimulate lipolysis in the white adipose tissue of mice. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Planta medica

VOLUME: 73

Page Numbers: 1255-9

Journal Abbreviation: Planta Med.

ISSN: 0032-0943

DAY: 24

MONTH: 09

YEAR: 2007

Constituents from the leaves of Nelumbo nucifera stimulate lipolysis in the white adipose tissue of mice. Information

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LANGUAGE: eng

NlmUniqueID: 66751

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Grant and Affiliation Information for Constituents from the leaves of Nelumbo nucifera stimulate lipolysis in the white adipose tissue of mice.

AFFILIATION: KIRIN Brewery Co., Ltd., Central Laboratories for Frontier Technology, Kanagawa, Japan.

Country: Germany

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MEDLINETA: Planta Med

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