Constant rate of steady-state self-antigen trafficking from skin to regional lymph nodes.

Constant rate of steady-state self-antigen trafficking from skin to regional lymph nodes. Research Abstract Details 

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Constant rate of steady-state self-antigen trafficking from skin to regional lymph nodes. Abstract Text:

Miya Yoshino,Hidetoshi Yamazaki,Leonard D Shultz,Shin-Ichi Hayashi,

It is suggested that dendritic cells (DCs) capture and present both foreign antigens such as components of pathogens as well as endogenous self-antigens. However, the magnitude of self-antigen trafficking to secondary lymphoid organs is still unclear. Here we show constitutive trafficking of self-antigens from skin to regional lymph nodes (LNs) quantitatively using a KRT14-Kitl transgenic mouse. This mouse model expresses the Kit ligand in keratinocytes, shows hyperpigmentation of the epidermis and exhibits constitutive accumulation of melanin granules (MGs) in skin regional LNs transported by Langerhans cells. Using an MG-solubilization technique, we revealed that 128 microg per week of MGs, a marker of self-antigens, accumulated in skin regional LNs and that the rate of accumulation was constant from 3 to 50 weeks. Activation markers such as CD40, CD54 and CD86 did not increase in the LNs, and abrogation of CD40 signaling did not affect the accumulation. Additionally, the total amount of MGs did not increase significantly following stimulation with intravenous LPS injections. These results suggest that the accumulation is not caused by inflammatory stimuli, and the steady-state trafficking of self-antigens is intrinsically maintained at a constant rate. Because the levels of self-antigens as well as the phenotype of these DCs are thought to be important in the strength of immune responses, the results may imply that the constant rate of trafficking of self-antigens is required for maintaining homeostatic conditions, such as self-tolerance.

Constant rate of steady-state self-antigen trafficking from skin to regional lymph nodes. Publishing Authors By Initials

M Yoshino,H Yamazaki,LD Shultz,S Hayashi,

For similar integumentary system: skin research abstracts see: integumentary system: skin research

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Constant rate of steady-state self-antigen trafficking from skin to regional lymph nodes. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: International immunology

VOLUME: 18

Page Numbers: 1541-8

Journal Abbreviation: Int. Immunol.

ISSN: 0953-8178

DAY: 11

MONTH: 09

YEAR: 2006

Constant rate of steady-state self-antigen trafficking from skin to regional lymph nodes. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8916182

Constant rate of steady-state self-antigen trafficking from skin to regional lymph nodes. Keywords Mesh Terms:

KEYWORDS: Skin

MESH TERMS: immunology

Chemical & Substance for Abstract: Constant rate of steady-state self-antigen trafficking from skin to regional lymph nodes. Information

Substance Name: CD40 Ligand

Registry Number: 147205-72-9

Grant and Affiliation Information for Constant rate of steady-state self-antigen trafficking from skin to regional lymph nodes.

AFFILIATION: Division of Immunology, Department of Molecular and Cellular Biology, School of Life Science, Faculty of Medicine, Tottori University, Yonago, 683-8503, Japan. myoshi@grape.med.tottori-u.ac.jp

Country: England

AGENCY: United States NCI

GRANT: CA34196

ACRONYM: CA

MEDLINETA: Int Immunol

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