Consistently stable or decreased body mass index in young adulthood and longitudinal changes in metabolic syndrome components: the Coronary Artery Risk Development in Young Adults Study.

Consistently stable or decreased body mass index in young adulthood and longitudinal changes in metabolic syndrome components: the Coronary Artery Risk Development in Young Adults Study. Research Abstract Details 

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Consistently stable or decreased body mass index in young adulthood and longitudinal changes in metabolic syndrome components: the Coronary Artery Risk Development in Young Adults Study. Abstract Text:

Donald M Lloyd-Jones,Kiang Liu,Laura A Colangelo,Lijing L Yan,Liviu Klein,Catherine M Loria,Cora E Lewis,Peter Savage,

BACKGROUND: Data are sparse regarding the association of stable body mass index (BMI) over the long term with metabolic syndrome components in young adults. METHODS AND RESULTS: Participants in the Coronary Artery Risk Development in Young Adults Study, including white and black adults 18 to 30 years of age at the initial examination in 1985 to 1986, were stratified into groups by baseline BMI and change in BMI (stable/decreased, increased >2 kg/m2, or fluctuating) across all 6 examinations between years 0 and 15 of the study. Changes in metabolic syndrome components were compared between groups. Among 1358 men and 1321 women, 16.3% maintained a stable BMI, 73.9% had an increased BMI, and 9.8% had a fluctuating BMI. Over 15 years, participants with stable BMI had essentially unchanged levels of metabolic syndrome components, regardless of baseline BMI, whereas those with increased BMI had progressively worsening levels. For example, men with a baseline BMI of 20.0 to 24.9 kg/m2 and stable BMI during follow-up had a mean increase of only 15 mg/dL in fasting triglycerides over 15 years compared with 65 mg/dL (P<0.001) in those whose BMI increased. Incidence of metabolic syndrome at year 15 was lower in the stable BMI group (2.2%) compared with the increased BMI group (18.8%; P<0.001). CONCLUSIONS: Adverse progression of metabolic syndrome components with advancing age may not be inevitable. Young adults who maintained stable BMI over time had minimal progression of risk factors and lower incidence of metabolic syndrome regardless of baseline BMI. Greater public health efforts should be aimed at long-term weight stabilization.

Consistently stable or decreased body mass index in young adulthood and longitudinal changes in metabolic syndrome components: the Coronary Artery Risk Development in Young Adults Study. Publishing Authors By Initials

DM Lloyd-Jones,K Liu,LA Colangelo,LL Yan,L Klein,CM Loria,CE Lewis,P Savage,

For similar pathological conditions, signs and symptoms: signs and symptoms: body weight: body weight changes: weight gain research abstracts see: pathological conditions, signs and symptoms: signs and symptoms: body weight: body weight changes: weight gain research

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Consistently stable or decreased body mass index in young adulthood and longitudinal changes in metabolic syndrome components: the Coronary Artery Risk Development in Young Adults Study. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Circulation

VOLUME: 115

Page Numbers: 1004-11

Journal Abbreviation: Circulation

ISSN: 1524-4539

DAY: 5

MONTH: 02

YEAR: 2007

Consistently stable or decreased body mass index in young adulthood and longitudinal changes in metabolic syndrome components: the Coronary Artery Risk Development in Young Adults Study. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 147763

Consistently stable or decreased body mass index in young adulthood and longitudinal changes in metabolic syndrome components: the Coronary Artery Risk Development in Young Adults Study. Keywords Mesh Terms:

KEYWORDS: Weight Gain

MESH TERMS: etiology

Chemical & Substance for Abstract: Consistently stable or decreased body mass index in young adulthood and longitudinal changes in metabolic syndrome components: the Coronary Artery Risk Development in Young Adults Study. Information

Substance Name: Blood Glucose

Registry Number: 0

Grant and Affiliation Information for Consistently stable or decreased body mass index in young adulthood and longitudinal changes in metabolic syndrome components: the Coronary Artery Risk Development in Young Adults Study.

AFFILIATION: Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, 680 N Lake Shore Dr, Ste 1102, Chicago, IL 60611, USA. dlj@northwestern.edu

Country: United States

AGENCY: United States NHLBI

GRANT: N01-HC-48049

ACRONYM: HC

MEDLINETA: Circulation

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