Conserved amino acid sequences in the bacterial sialyltransferases belonging to Glycosyltransferase family 80.

Conserved amino acid sequences in the bacterial sialyltransferases belonging to Glycosyltransferase family 80. Research Abstract Details 

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Conserved amino acid sequences in the bacterial sialyltransferases belonging to Glycosyltransferase family 80. Abstract Text:

Takeshi Yamamoto,Masako Ichikawa,Yoshimitsu Takakura,Takeshi Yamamoto,Masako Ichikawa,Yoshimitsu Takakura,

Sialyltransferases are key enzymes for the biosynthesis of sialyl-glycoproteins and sialyl-lipids and the genes encoding sialyltransferases have been cloned from mammalian and bacterial source. In the mammalian sialyltransferase, existence of three conserved regions, named sialyl motifs, has been demonstrated. On the other hand, two short motifs, named D/E-D/E-G motif and HP motif, have been reported in the bacterial sialyltransferases very recently. From the results of multiple alignments among the sialyltransferases belonging to Glycosyltransferase family 80 and crystal structures of two reported sialyltransferases, it is clearly demonstrated that the third conserved-functional motif exists in the bacterial sialyltransferases that have been classified into Glycosyltransferase family 80 in this study.

Conserved amino acid sequences in the bacterial sialyltransferases belonging to Glycosyltransferase family 80. Publishing Authors By Initials

T Yamamoto,M Ichikawa,Y Takakura,T Yamamoto,M Ichikawa,Y Takakura,

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Conserved amino acid sequences in the bacterial sialyltransferases belonging to Glycosyltransferase family 80. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Biochemical and biophysical research communication

VOLUME: 365

Page Numbers: 340-3

Journal Abbreviation: Biochem. Biophys. Res. Commun.

ISSN: 1090-2104

DAY: 13

MONTH: 11

YEAR: 2007

Conserved amino acid sequences in the bacterial sialyltransferases belonging to Glycosyltransferase family 80. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Conserved amino acid sequences in the bacterial sialyltransferases belonging to Glycosyltransferase family 80.

AFFILIATION: Glycotechnology Business Unit, Japan Tobacco Inc., 700 Higashibara, Iwata, Shizuoka 438-0802, Japan. takeshi.yamamoto@ims.jti.co.jp

Country: United States

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MEDLINETA: Biochem Biophys Res Commun

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