Consequences of telomere shortening at an active VSG expression site in telomerase-deficient Trypanosoma brucei.

Consequences of telomere shortening at an active VSG expression site in telomerase-deficient Trypanosoma brucei. Research Abstract Details 

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Consequences of telomere shortening at an active VSG expression site in telomerase-deficient Trypanosoma brucei. Abstract Text:

Oliver Dreesen,George A M Cross,

Trypanosoma brucei evades the host immune response by sequential expression of a large family of variant surface glycoproteins (VSG) from one of approximately 20 subtelomeric expression sites (ES). VSG transcription is monoallelic, and little is known about the regulation of antigenic switching. To explore whether telomere length could affect antigenic switching, we created a telomerase-deficient cell line, in which telomeres shortened at a rate of 3 to 6 bp at each cell division. Upon reaching a critical length, short silent ES telomeres were stabilized by a telomerase-independent mechanism. The active ES telomere progressively shortened and frequently broke. Upon reaching a critical length, the short active ES telomere stabilized, but the transcribed VSG was gradually lost from the population and replaced by a new VSG through duplicative gene conversion. We propose a model in which subtelomeric-break-induced replication-mediated repair at a short ES telomere leads to duplicative gene conversion and expression of a new VSG.

Consequences of telomere shortening at an active VSG expression site in telomerase-deficient Trypanosoma brucei. Publishing Authors By Initials

O Dreesen,GA Cross,

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Consequences of telomere shortening at an active VSG expression site in telomerase-deficient Trypanosoma brucei. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Eukaryotic cell

VOLUME: 5

Page Numbers: 2114-9

Journal Abbreviation: Eukaryotic Cell

ISSN: 1535-9778

DAY: 27

MONTH: 10

YEAR: 2006

Consequences of telomere shortening at an active VSG expression site in telomerase-deficient Trypanosoma brucei. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 101130731

Consequences of telomere shortening at an active VSG expression site in telomerase-deficient Trypanosoma brucei. Keywords Mesh Terms:

KEYWORDS: Variant Surface Glycoproteins, Trypanoso

MESH TERMS: immunology

Chemical & Substance for Abstract: Consequences of telomere shortening at an active VSG expression site in telomerase-deficient Trypanosoma brucei. Information

Substance Name: Telomerase

Registry Number: EC 2.7.7.49

Grant and Affiliation Information for Consequences of telomere shortening at an active VSG expression site in telomerase-deficient Trypanosoma brucei.

AFFILIATION: Laboratory of Molecular Parasitology, The Rockefeller University, 1230 York Avenue, New York, NY 10021-6307, USA.

Country: United States

AGENCY: United States NIAID

GRANT: AI 50614

ACRONYM: AI

MEDLINETA: Eukaryot Cell

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