Consensus features in amyloid fibrils: sheet-sheet recognition via a (polar or nonpolar) zipper structure.

Consensus features in amyloid fibrils: sheet-sheet recognition via a (polar or nonpolar) zipper structure. Research Abstract Details 

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Consensus features in amyloid fibrils: sheet-sheet recognition via a (polar or nonpolar) zipper structure. Abstract Text:

Jie Zheng,Buyong Ma,Ruth Nussinov,

Amyloid fibrils characterized as highly intractable thread-like species are associated with many neurodegenerative diseases. Although neither the mechanism of amyloid formation nor the origin of amyloid toxicity is currently completely understood, the detailed three-dimensional atomic structures of the yeast protein Sup35 and Abeta amyloid protein determined by recent experiments provide the first and important step towards the comprehension of the pathogenesis and aggregation mechanisms of amyloid diseases. By analyzing these two amyloid peptides which have available crystal structures and other amyloid sequences with proposed structures using computational simulations, we delineate three common features in amyloid organizations and amyloid structures. These could contribute to an improved understanding of the molecular mechanism of amyloid formation, the nature of the aggregation driving forces that stabilize these structures and the development of potential therapeutic agents against amyloid diseases.

Consensus features in amyloid fibrils: sheet-sheet recognition via a (polar or nonpolar) zipper structure. Publishing Authors By Initials

J Zheng,B Ma,R Nussinov,

For similar proteins: fungal proteins: saccharomyces cerevisiae proteins research abstracts see: proteins: fungal proteins: saccharomyces cerevisiae proteins research

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Consensus features in amyloid fibrils: sheet-sheet recognition via a (polar or nonpolar) zipper structure. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Physical biology

VOLUME: 3

Page Numbers: P1-4

Journal Abbreviation:

ISSN: 1478-3975

DAY: 3

MONTH: 10

YEAR: 2006

Consensus features in amyloid fibrils: sheet-sheet recognition via a (polar or nonpolar) zipper structure. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 101197454

Consensus features in amyloid fibrils: sheet-sheet recognition via a (polar or nonpolar) zipper structure. Keywords Mesh Terms:

KEYWORDS: Saccharomyces cerevisiae Proteins

MESH TERMS: chemistry

Chemical & Substance for Abstract: Consensus features in amyloid fibrils: sheet-sheet recognition via a (polar or nonpolar) zipper structure. Information

Substance Name: SUP35 protein, S cerevisiae

Registry Number: 133737-87-8

Grant and Affiliation Information for Consensus features in amyloid fibrils: sheet-sheet recognition via a (polar or nonpolar) zipper structure.

AFFILIATION: Basic Research Program, SAIC-Frederick, Inc., Center for Cancer Research Nanobiology Program, NCI-Frederick, Frederick, MD 21702, USA.

Country: England

AGENCY: United States NCI

GRANT: N01-CO-12400

ACRONYM: CO

MEDLINETA: Phys Biol

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