Conformational switching in the fungal light sensor Vivid.

Conformational switching in the fungal light sensor Vivid. Research Abstract Details 

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Conformational switching in the fungal light sensor Vivid. Abstract Text:

Brian D Zoltowski,Carsten Schwerdtfeger,Joanne Widom,Jennifer J Loros,Alexandrine M Bilwes,Jay C Dunlap,Brian R Crane,

The Neurospora crassa photoreceptor Vivid tunes blue-light responses and modulates gating of the circadian clock. Crystal structures of dark-state and light-state Vivid reveal a light, oxygen, or voltage Per-Arnt-Sim domain with an unusual N-terminal cap region and a loop insertion that accommodates the flavin cofactor. Photoinduced formation of a cystein-flavin adduct drives flavin protonation to induce an N-terminal conformational change. A cysteine-to-serine substitution remote from the flavin adenine dinucleotide binding site decouples conformational switching from the flavin photocycle and prevents Vivid from sending signals in Neurospora. Key elements of this activation mechanism are conserved by other photosensors such as White Collar-1, ZEITLUPE, ENVOY, and flavin-binding, kelch repeat, F-BOX 1 (FKF1).

Conformational switching in the fungal light sensor Vivid. Publishing Authors By Initials

BD Zoltowski,C Schwerdtfeger,J Widom,JJ Loros,AM Bilwes,JC Dunlap,BR Crane,

For similar biochemical phenomena, metabolism, and nutrition: biochemical phenomena: molecular structure: molecular conformation: protein conformation: protein structure, tertiary research abstracts see: biochemical phenomena, metabolism, and nutrition: biochemical phenomena: molecular structure: molecular conformation: protein conformation: protein structure, tertiary research

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Conformational switching in the fungal light sensor Vivid. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Science (New York, N.Y.)

VOLUME: 316

Page Numbers: 1054-7

Journal Abbreviation: Science

ISSN: 1095-9203

DAY: 18

MONTH: May

YEAR: 2007

Conformational switching in the fungal light sensor Vivid. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 404511

Conformational switching in the fungal light sensor Vivid. Keywords Mesh Terms:

KEYWORDS: Protein Structure, Tertiary

MESH TERMS: chemistry

Chemical & Substance for Abstract: Conformational switching in the fungal light sensor Vivid. Information

Substance Name: Flavin-Adenine Dinucleotide

Registry Number: 146-14-5

Grant and Affiliation Information for Conformational switching in the fungal light sensor Vivid.

AFFILIATION: Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853, USA.

Country: United States

AGENCY: United States NIGMS

GRANT: R37GM34985

ACRONYM: GM

MEDLINETA: Science

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