Confocal theta line-scanning microscope for imaging human tissues.

Confocal theta line-scanning microscope for imaging human tissues. Research Abstract Details 

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Confocal theta line-scanning microscope for imaging human tissues. Abstract Text:

Peter J Dwyer,Charles A DiMarzio,Milind Rajadhyaksha,

A confocal reflectance theta line-scanning microscope demonstrates imaging of nuclear and cellular morphology in human skin and oral mucosa in vivo. The illumination and detection are through a divided objective lens pupil, resulting in a theta-microscope configuration. A line is directly scanned in the pupil and descanned onto a linear detector array such that the theta line scanner consists of only seven main optical components. The experimentally measured lateral resolution is 1.0 microm and optical section thickness is 1.7 microm under nominal conditions at 830 nm wavelength. Through full-thickness human epidermis (i.e., in the dermis) the measured lateral resolution is 1.7 microm and the optical section thickness is 9.2 microm. The lateral resolution, sectioning, and image quality in epidermal (epithelial) tissue is comparable to that of point scanning confocal microscopy.

Confocal theta line-scanning microscope for imaging human tissues. Publishing Authors By Initials

PJ Dwyer,CA DiMarzio,M Rajadhyaksha,

For similar integumentary system: skin research abstracts see: integumentary system: skin research

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Confocal theta line-scanning microscope for imaging human tissues. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Applied optics

VOLUME: 46

Page Numbers: 1843-51

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ISSN: 0003-6935

DAY: 1

MONTH: Apr

YEAR: 2007

Confocal theta line-scanning microscope for imaging human tissues. Information

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LANGUAGE: eng

NlmUniqueID: 247660

Confocal theta line-scanning microscope for imaging human tissues. Keywords Mesh Terms:

KEYWORDS: Skin

MESH TERMS: cytology

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Grant and Affiliation Information for Confocal theta line-scanning microscope for imaging human tissues.

AFFILIATION: Department of Electrical and Computer Engineering, Northeastern University, MA 02115, USA. pdwyer@cri-inc.com

Country: United States

AGENCY: United States NCI

GRANT: 2R44CA93106

ACRONYM: CA

MEDLINETA: Appl Opt

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