Conditioned eyeblink learning is formed and stored without cerebellar granule cell transmission.

Conditioned eyeblink learning is formed and stored without cerebellar granule cell transmission. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Conditioned eyeblink learning is formed and stored without cerebellar granule cell transmission. Abstract Text:

Norio Wada,Yasushi Kishimoto,Dai Watanabe,Masanobu Kano,Tomoo Hirano,Kazuo Funabiki,Shigetada Nakanishi,Norio Wada,Yasushi Kishimoto,Dai Watanabe,Masanobu Kano,Tomoo Hirano,Kazuo Funabiki,Shigetada Nakanishi,Norio Wada,Yasushi Kishimoto,Dai Watanabe,Masanobu Kano,Tomoo Hirano,Kazuo Funabiki,Shigetada Nakanishi,

Classical conditioning of the eyeblink reflex is elicited by paired presentation of a conditioned stimulus and an unconditioned stimulus and represents a basic form of cerebellum-dependent motor learning. Purkinje cells and the deep nuclei receive convergent information of conditioned stimulus and unconditioned stimulus through the mossy fiber and climbing fiber projections, respectively. To explore the relative importance of these neural circuits and the underlying mechanism in associative eyeblink learning, we adopted a novel gene-manipulating technique, termed reversible neurotransmission blocking (RNB). In this technology, cerebellar granule cells specifically expressed neurotransmission-blocking tetanus toxin in a doxycycline (DOX)-dependent manner. Extracellular recording of Purkinje cells in awake RNB mice revealed that DOX treatment and withdrawal reversibly turned off and on simple spikes elicited by granule cell inputs, respectively, without interference with complex spikes evoked by climbing fiber inputs. Blockade of granule cell inputs to Purkinje cells abolished eyeblink conditioned responses (CRs) in a DOX-dependent manner. Importantly, when granule cell inputs recovered by removal of DOX, normal CRs were immediately produced in the DOX-treated, CR-negative RNB mice from the beginning of reconditioning. This learning process in RNB mice during DOX treatment was completely abolished by bilateral lesion of the interpositus nucleus before eyeblink conditioning. These results indicate that the convergent information at the interpositus nucleus is critical for acquisition and storage of learning in intimate association with the Purkinje cell circuit for expression of CRs in eyeblink conditioning.

Conditioned eyeblink learning is formed and stored without cerebellar granule cell transmission. Publishing Authors By Initials

N Wada,Y Kishimoto,D Watanabe,M Kano,T Hirano,K Funabiki,S Nakanishi,N Wada,Y Kishimoto,D Watanabe,M Kano,T Hirano,K Funabiki,S Nakanishi,N Wada,Y Kishimoto,D Watanabe,M Kano,T Hirano,K Funabiki,S Nakanishi,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Conditioned eyeblink learning is formed and stored without cerebellar granule cell transmission. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Proceedings of the National Academy of Sciences of

VOLUME: 104

Page Numbers: 16690-5

Journal Abbreviation: Proc. Natl. Acad. Sci. U.S.A.

ISSN: 0027-8424

DAY: 8

MONTH: 10

YEAR: 2007

Conditioned eyeblink learning is formed and stored without cerebellar granule cell transmission. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7505876

Conditioned eyeblink learning is formed and stored without cerebellar granule cell transmission. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Conditioned eyeblink learning is formed and stored without cerebellar granule cell transmission. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Conditioned eyeblink learning is formed and stored without cerebellar granule cell transmission.

AFFILIATION: Department of Systems Biology, Osaka Bioscience Institute, Suita, Osaka 565-0874, Japan.

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Proc Natl Acad Sci U S A

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Conditioned eyeblink learning is formed and stored without cerebellar granule cell transmission Related Publications

• A carbohydrate recognition-based drug delivery and controlled release system using intraperitoneal macrophages as a cellular vehicle.
• A new type of imido group donor: synthesis and characterization of sulfonylimino-lambda(3)-bromane that acts as a nitrenoid in the aziridination of olefins at room temperature under metal-free conditions.
• A serious clinical course of a very elderly patient with takotsubo cardiomyopathy.
• A2E, a fluorophore of RPE lipofuscin, can destabilize membrane.
• ATP plays a role in neurite stimulation with activated mast cells.
• Aryl-substituted C3-bridged oligopyrroles as anion receptors for formation of supramolecular organogels.
• Atsuyoshi Takao.
• Biologically active macrocyclic diterpenoids from chinese drug "fáng féng cáo" I. Isolation and structure1.
• Characterization of dihydro-A2PE: an intermediate in the A2E biosynthetic pathway.
• Conditioned eyeblink learning is formed and stored without cerebellar granule cell transmission.
• Doxycycline attenuated lung injury by its biological effect apart from its antimicrobial function.
• Drug transporters as targets for cancer chemotherapy.
• Effects of bone morphogenetic protein-2 and transforming growth factor beta1 on gene expression of transcription factors, AJ18 and Runx2 in cultured osteoblastic cells.
• Effects of salmeterol in patients with persistent asthma receiving inhaled corticosteroid plus theophylline.
• Impact of lifestyle intervention on physical activity and diet of Japanese workers.
• Increased thrombogenesity in patients with cyanotic congenital heart disease.
• Intracranial carotid calcification on CT images as an indicator of atheromatous plaque: analysis of high-resolution CTA images using a 64-multidetector scanner.
• Magnetic resonance imaging of brain abscess with hemorrhage: implications for the mechanism of hemorrhage.
• NBD-conjugated biosurfactant (MEL-A) shows a new pathway for transfection.
• Proposal for sets of se NMR chemical shifts in planar and perpendicular orientations of aryl group and the applications.
• Revascularization of trachea in lung and tracheal transplantation.
• Role of aldose reductase in the peritoneal changes of patients undergoing peritoneal dialysis.
• Structural organization of the mouse metabotropic glutamate receptor subtype 3 gene and its regulation by growth factors in cultured cortical astrocytes.
• Successful treatment of refractory chronic necrotizing pulmonary aspergillosis with micafungin.
• Superoxidation of retinoic acid.
• Synthesis of novel ginkgolide photoaffinity-biotin probes.
• Takusan: a large gene family that regulates synaptic activity.
• The role of Sertoli cells in the differentiation and exclusion of rat testicular germ cells in primary culture.
• [Molecular toxicology leaded by young scientists-chemical toxicology and transcriptional factors]
• [Search and structural elucidation of medicinal products from the vegetable kingdom (crude drugs and plant materials)]