Concordant over-expression of transcription factor Sp1 and vascular endothelial growth factor in extramammary Paget's disease.

Concordant over-expression of transcription factor Sp1 and vascular endothelial growth factor in extramammary Paget's disease. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Concordant over-expression of transcription factor Sp1 and vascular endothelial growth factor in extramammary Paget's disease. Abstract Text:

BACKGROUND: Specificity protein 1 (Sp1) is a transcription factor and shown to be a sequence-specific DNA-binding protein that activate a broad and diverse spectrum of mammalian gene, such as vascular endothelial growth factor (VEGF) gene. But the expression of Sp1 and VEGF has not previously been investigated in extramammary Paget's disease (EMPD). METHODS: To investigate the expression of Sp1 and VEGF proteins in EMPD and to assess their relationships and potential contribution to malignant transduction of EMPD, paraffin-embedded EMPD specimens (35 tissue samples from 33 patients with primary EMPD, including two samples of metastatic lymph nodes from two patients) were subjected to immunohistochemical staining for Sp1 and VEGF. RESULTS: All of the 35 EMPD specimens, including all of six invasive EMPD and two metastatic lymph node specimens, showed strong nuclear positive staining for Sp1 and strong cytoplasmic positive staining for VEGF. The expression levels (% positive cells) of Sp1 and VEGF in EMPD were significantly higher than those of normal skin (NS). There was a significantly high correlation between expression levels of Sp1 and VEGF in EMPD. CONCLUSIONS: The present study reveals that the concordant over-expression of Sp1 and VEGF may play a pivotal role in the tumorigenesis and further malignant transduction of EMPD.

Concordant over-expression of transcription factor Sp1 and vascular endothelial growth factor in extramammary Paget's disease. Publishing Authors By Initials

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Concordant over-expression of transcription factor Sp1 and vascular endothelial growth factor in extramammary Paget's disease. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: International journal of dermatology

VOLUME: 47

Page Numbers: 562-6

Journal Abbreviation: Int. J. Dermatol.

ISSN: 1365-4362

DAY: 14

MONTH: Jun

YEAR: 2008

Concordant over-expression of transcription factor Sp1 and vascular endothelial growth factor in extramammary Paget's disease. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 243704

Concordant over-expression of transcription factor Sp1 and vascular endothelial growth factor in extramammary Paget's disease. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Concordant over-expression of transcription factor Sp1 and vascular endothelial growth factor in extramammary Paget's disease. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Concordant over-expression of transcription factor Sp1 and vascular endothelial growth factor in extramammary Paget's disease.

AFFILIATION: Department of Dermatology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Int J Dermatol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Concordant over-expression of transcription factor Sp1 and vascular endothelial growth factor in extramammary Paget's disease Related Publications

• Assessment of abnormal blood flow and efficacy of treatment in patients with systemic sclerosis using a newly developed microwireless laser Doppler flowmeter and arm-raising test.
• Association factors for atopic dermatitis in nursery school children in Ishigaki islands - Kyushu University Ishigaki Atopic Dermatitis Study (KIDS).
• Case of adult T-cell leukemia/lymphoma manifesting marked purpura.
• Clavus detected incidentally by positron emission tomography with computed tomography.
• Clinical experiences with a new anti-cancer compound hematoporphyrin mercury complex, disodium salt.
• Clinical experiences with the streptococcal anticancer preparation, OK-432 (NSC-B116209).
• Concentrations of polychlorinated dibenzo-p-dioxins, polychlorinated dibenzofurans, and dioxin-like polychlorinated biphenyls in blood and breast milk collected from 60 mothers in Sapporo City, Japan.
• Concentrations of polychlorinated dibenzo-p-dioxins, polychlorinated dibenzofurans, and dioxin-like polychlorinated biphenyls in blood collected from 195 pregnant women in Sapporo City, Japan.
• Concordant over-expression of transcription factor Sp1 and vascular endothelial growth factor in extramammary Paget's disease.
• Concordant overexpression of p-FAK and p-ERK1/2 in extramammary Paget's disease.
• Congener-specific analysis of non-dioxin-like polychlorinated biphenyls in blood collected from 127 elderly residents in Nakagawa Town, Fukuoka Prefecture, Japan.
• Congener-specific analysis of non-dioxin-like polychlorinated biphenyls in blood collected from 195 pregnant women in Sapporo City, Japan.
• Cutaneous Langerhans cell histiocytosis in an elderly man successfully treated with narrowband ultraviolet B.
• Dendritic cells: ontogeny.
• Dermatological legal claims in Japan.
• Detection of autoantibodies to desmoplakin in a patient with oral erythema multiforme.
• Differential expression of two new members of the p53 family, p63 and p73, in extramammary Paget's disease.
• Excellent clinical results with a new preparation for chemical peeling in acne: 30% salicylic acid in polyethylene glycol vehicle.
• Hair follicle nevus - A dermoscopic approach.
• Herpes zoster-associated voiding dysfunction in hematopoietic malignancy patients.
• Increased expression of an epidermal stem cell marker, cytokeratin 19, in cutaneous squamous cell carcinoma.
• Interdigital amelanotic spindle-cell melanoma mimicking an inflammatory process due to dermatophytosis.
• Kasabach-merritt syndrome associated with angiosarcoma of the scalp successfully treated with chemoradiotherapy.
• Long-term effects of polychlorinated biphenyls and dioxins on pregnancy outcomes in women affected by the yusho incident.
• Stromal CD10 expression is correlated with invasiveness and proliferation of extramammary Paget disease.
• Successful treatment of nail bed hypoplasia after nail loss by acrylic nail.
• Suplatast/tacrolimus combination therapy for refractory facial erythema in adult patients with atopic dermatitis: a meta-analysis study.
• Traumatic neuroma of the lower lip with intraepithelial nerve fibers.
• Vitiligo onset removes congenital nevocellular nevus cells.