Concise review: hematopoietic stem cells and tissue stem cells: current concepts and unanswered questions.

Concise review: hematopoietic stem cells and tissue stem cells: current concepts and unanswered questions. Research Abstract Details 

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Concise review: hematopoietic stem cells and tissue stem cells: current concepts and unanswered questions. Abstract Text:

Donald Metcalf,Donald Metcalf,Donald Metcalf,

The term hematopoietic stem cells has at times been used to include a miscellany of precursor cells ranging from multipotential self-generating cells to lineage-restricted progenitors with little capacity for self-generation. It is probable that the stem cells of other tissues also vary widely in their multipotentiality and proliferative capacity. This review questions several dogmas regarding the self-generative capacity of various hematopoietic cells, the single episodic origin of hematopoietic cells, and the irreversible nature of progressive mature cell formation in individual hematopoietic lineages. Disclosure of potential conflicts of interest is found at the end of this article.

Concise review: hematopoietic stem cells and tissue stem cells: current concepts and unanswered questions. Publishing Authors By Initials

D Metcalf,D Metcalf,D Metcalf,

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Concise review: hematopoietic stem cells and tissue stem cells: current concepts and unanswered questions. Journal Published:

PUBLICATION TYPE: Review

Journal: Stem cells (Dayton, Ohio)

VOLUME: 25

Page Numbers: 2390-5

Journal Abbreviation: Stem Cells

ISSN: 1549-4918

DAY: 9

MONTH: 08

YEAR: 2007

Concise review: hematopoietic stem cells and tissue stem cells: current concepts and unanswered questions. Information

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LANGUAGE: eng

NlmUniqueID: 9304532

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Grant and Affiliation Information for Concise review: hematopoietic stem cells and tissue stem cells: current concepts and unanswered questions.

AFFILIATION: The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia. metcalf@wehi.edu.au

Country: United States

AGENCY: United States NCI

GRANT: CA22556

ACRONYM: CA

MEDLINETA: Stem Cells

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