Concerning the Synthesis of the Tedanolide C(13)-C(23) Fragment via Anti-Aldol Reaction.

Concerning the Synthesis of the Tedanolide C(13)-C(23) Fragment via Anti-Aldol Reaction. Research Abstract Details 

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Concerning the Synthesis of the Tedanolide C(13)-C(23) Fragment via Anti-Aldol Reaction. Abstract Text:

Synthesis of C(13)-C(23) aldehyde 4, an important intermediate in a planned total synthesis of tedanolide, is described. The stereoselectivity of the key anti-aldol reaction of aldehyde 5 and ketone 6 (en route to 4) perfectly tracks the enantiomeric purity of 5. It is demonstrated that aldehyde 24, a precursor of 5, undergoes facile epimerization during a Swern oxidation and stabilized ylide olefination sequence.

Concerning the Synthesis of the Tedanolide C(13)-C(23) Fragment via Anti-Aldol Reaction. Publishing Authors By Initials

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Concerning the Synthesis of the Tedanolide C(13)-C(23) Fragment via Anti-Aldol Reaction. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Organic letters

VOLUME: 10

Page Numbers: 2059-62

Journal Abbreviation: Org. Lett.

ISSN: 1523-7060

DAY: 19

MONTH: 04

YEAR: 2008

Concerning the Synthesis of the Tedanolide C(13)-C(23) Fragment via Anti-Aldol Reaction. Information

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LANGUAGE: eng

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