Concentrations of individual serum or plasma bile acids in workers exposed to chlorinated aliphatic hydrocarbons.

Concentrations of individual serum or plasma bile acids in workers exposed to chlorinated aliphatic hydrocarbons. Research Abstract Details 

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Concentrations of individual serum or plasma bile acids in workers exposed to chlorinated aliphatic hydrocarbons. Abstract Text:

Individual serum or plasma bile acid concentrations were measured by high performance liquid chromatography in two groups of workers with differing exposures: to hexachlorobutadiene (HCBD) and a mixture of other chlorinated solvents (SOLVENT) in study A; and trichloroethylene (TCE) in study B. Exposures to HCBD and TCE were associated with highly significant increases in a number of individual and summed bile acid measures, with a dose effect relation shown for HCBD. Exposure to SOLVENT was associated with significant decreases in three bile acid measures but this may have been due to misclassification of exposure. No association was found between any of the exposures and any of the standard tests of liver function. This preliminary study suggests that some chlorinated hydrocarbons are associated with raised bile acid concentrations in the blood of exposed workers. It may be that the changes in such concentrations reflect early and small disturbances of liver function. The significance and mechanism of the changes are yet to be determined.

Concentrations of individual serum or plasma bile acids in workers exposed to chlorinated aliphatic hydrocarbons. Publishing Authors By Initials

For similar organic chemicals: hydrocarbons: hydrocarbons, halogenated: hydrocarbons, chlorinated: trichloroethylene research abstracts see: organic chemicals: hydrocarbons: hydrocarbons, halogenated: hydrocarbons, chlorinated: trichloroethylene research

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Concentrations of individual serum or plasma bile acids in workers exposed to chlorinated aliphatic hydrocarbons. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: British journal of industrial medicine

VOLUME: 49

Page Numbers: 700-5

Journal Abbreviation: Br J Ind Med

ISSN: 0007-1072

DAY: 28

MONTH: Oct

YEAR: 1992

Concentrations of individual serum or plasma bile acids in workers exposed to chlorinated aliphatic hydrocarbons. Information

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LANGUAGE: eng

NlmUniqueID: 370637

Concentrations of individual serum or plasma bile acids in workers exposed to chlorinated aliphatic hydrocarbons. Keywords Mesh Terms:

KEYWORDS: Trichloroethylene

MESH TERMS: adverse effects

Chemical & Substance for Abstract: Concentrations of individual serum or plasma bile acids in workers exposed to chlorinated aliphatic hydrocarbons. Information

Substance Name: hexachlorobutadiene

Registry Number: 87-68-3

Grant and Affiliation Information for Concentrations of individual serum or plasma bile acids in workers exposed to chlorinated aliphatic hydrocarbons.

AFFILIATION: National Institute of Occupational Health and Safety, University of Sydney, NSW, Australia.

Country: ENGLAND

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MEDLINETA: Br J Ind Med

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