COMT genotype increases risk for bipolar I disorder and influences neurocognitive performance.

COMT genotype increases risk for bipolar I disorder and influences neurocognitive performance. Research Abstract Details 

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COMT genotype increases risk for bipolar I disorder and influences neurocognitive performance. Abstract Text:

Katherine E Burdick,Birgit Funke,Joseph F Goldberg,John A Bates,Judith Jaeger,Raju Kucherlapati,Anil K Malhotra,

OBJECTIVES: Bipolar disorder (BPD) is an affective disorder characterized by episodes of depression and mania. Cognitive impairment in patients with BPD is common and recent data suggest that it may represent a trait-like feature of the illness, as it persists during periods of wellness and co-segregates in families of bipolar patients. This suggests an underlying genetic predisposition towards cognitive impairment in patients with BPD; however, there have been few studies investigating the effects of candidate genes on this symptom domain. The catechol-O-methyl transferase (COMT) gene is located on chromosome 22q11 and is involved in the metabolism of dopamine and norepinephrine. A large body of evidence suggests that COMT is associated with cognitive performance in patients with schizophrenia and in healthy volunteers but there have been no reports of its relationship to cognition in BPD. METHODS: We genotyped 52 Caucasian bipolar I probands and 102 Caucasian healthy controls across four single nucleotide polymorphisms (SNPs) within the COMT gene and administered a cognitive screening battery. We first assessed the relationship between COMT genotype and diagnosis and then tested for effects on cognition. RESULTS: We observed a modest but significant association between SNP rs165599 and BPD I, with the g allele being over-represented in cases versus controls (odds ratio, OR = 2.41; allelic p = 0.02; genotypic p = 0.04). Further, we found a relationship between the risk allele at this SNP and poorer performance on measures of verbal memory [California Verbal Learning Test (CVLT) Trials 1-5; p = 0.005, eta(2) = 0.07] particularly with regard to prefrontal aspects of learning (CVLT semantic cluster; p = 0.037, eta(2) = 0.04) in patients with BPD and in healthy controls. The common Val158Met polymorphism was not associated with diagnosis (p = 0.32) or cognition in our sample. CONCLUSIONS: These data suggest that COMT genetic variation at SNP rs165599 is associated with BPD I and influences prefrontal aspects of verbal memory in bipolar patients and healthy controls.

COMT genotype increases risk for bipolar I disorder and influences neurocognitive performance. Publishing Authors By Initials

KE Burdick,B Funke,JF Goldberg,JA Bates,J Jaeger,R Kucherlapati,AK Malhotra,

For similar investigative techniques: epidemiologic methods: statistics as topic: probability: risk: risk factors research abstracts see: investigative techniques: epidemiologic methods: statistics as topic: probability: risk: risk factors research

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COMT genotype increases risk for bipolar I disorder and influences neurocognitive performance. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Bipolar disorders

VOLUME: 9

Page Numbers: 370-6

Journal Abbreviation: Bipolar Disord

ISSN: 1398-5647

DAY: 3

MONTH: Jun

YEAR: 2007

COMT genotype increases risk for bipolar I disorder and influences neurocognitive performance. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 100883596

COMT genotype increases risk for bipolar I disorder and influences neurocognitive performance. Keywords Mesh Terms:

KEYWORDS: Risk Factors

MESH TERMS: genetics

Chemical & Substance for Abstract: COMT genotype increases risk for bipolar I disorder and influences neurocognitive performance. Information

Substance Name: Catechol O-Methyltransferase

Registry Number: EC 2.1.1.6

Grant and Affiliation Information for COMT genotype increases risk for bipolar I disorder and influences neurocognitive performance.

AFFILIATION: Department of Psychiatry Research, Zucker Hillside Hospital, North Shore-Long Island Jewish Health System, Glen Oaks, NY 11004, USA. kburdick@lij.edu

Country: Denmark

AGENCY: United States NIMH

GRANT: K23MH001760

ACRONYM: MH

MEDLINETA: Bipolar Disord

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