Computer-based analysis of dynamic QT changes: toward high precision and individual rate correction.

Computer-based analysis of dynamic QT changes: toward high precision and individual rate correction. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Computer-based analysis of dynamic QT changes: toward high precision and individual rate correction. Abstract Text:

BACKGROUND: New strategies are needed to improve the results of automatic measurement of the various parts of the ECG signal and their dynamic changes. METHODS: The EClysis software processes digitally-recorded ECGs from up to 12 leads at 500 Hz, using strictly defined algorithms to detect the PQRSTU points and to measure ECG intervals and amplitudes. Calculations are made on the averaged curve of each sampling period (beat group) or as means +/- SD for beat groups, after being analyzed at the individual beat level in each lead. Resulting data sets can be exported for further statistical analyses. Using QT and R-R measured on beat level, an individual correction for the R-R dependence can be performed. RESULTS: EClysis assigns PQRSTU points and intervals in a sensitive and highly reproducible manner, with coefficients of variation in ECG intervals corresponding to ca. 2 ms in the simulated ECG. In the normal ECG, the CVs are 2% for QRS, 0.8% for QT, and almost 6% for PQ intervals. EClysis highlights the increase in QT intervals and the decrease of T-wave amplitudes during almokalant infusion versus placebo. Using the observed linear or exponential relationships to adjust QT for R-R dependence in healthy subjects, one can eliminate this dependence almost completely by individualized correction. CONCLUSIONS: The EClysis system provides a precise and reproducible method to analyze ECGs.

Computer-based analysis of dynamic QT changes: toward high precision and individual rate correction. Publishing Authors By Initials

For similar information science: computing methodologies: software research abstracts see: information science: computing methodologies: software research

PUBMED ID PMID:

MEDLINE DATE:

Computer-based analysis of dynamic QT changes: toward high precision and individual rate correction. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Annals of noninvasive electrocardiology : the offi

VOLUME: 7

Page Numbers: 289-301

Journal Abbreviation: Ann Noninvasive Electrocardiol

ISSN: 1082-720X

DAY: 10

MONTH: Oct

YEAR: 2002

Computer-based analysis of dynamic QT changes: toward high precision and individual rate correction. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9607443

Computer-based analysis of dynamic QT changes: toward high precision and individual rate correction. Keywords Mesh Terms:

KEYWORDS: Software

MESH TERMS: pharmacology

Chemical & Substance for Abstract: Computer-based analysis of dynamic QT changes: toward high precision and individual rate correction. Information

Substance Name: almokalant

Registry Number: 123955-10-2

Grant and Affiliation Information for Computer-based analysis of dynamic QT changes: toward high precision and individual rate correction.

AFFILIATION: Experimental Medicine, AstraZeneca R & D Mölndal, S-431 83 Mölndal, Sweden. Corina.Dota@astrazeneca.com

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Ann Noninvasive Electrocardiol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Computer-based analysis of dynamic QT changes: toward high precision and individual rate correction Related Publications

• An AAC Personnel Framework: Adults with Acquired Complex Communication Needs.
• Computer-based analysis of dynamic QT changes: toward high precision and individual rate correction.
• Folic acid activity in homogenates of rat liver.
• Prevention of nuclear fusion and mitosis and inhibition of desoxyribonuclease by d-usnic acid.
• The use of a hog kidney conjugase in the assay of plant materials for folic acid.
• What is happening to the profession?
• What's right and wrong in my world of medicine.
• [Myoepithelial differentiation of basal cell and metatypic skin cancer]