Computer-assisted lateralization of unilateral temporal lobe epilepsy using Z-score parametric F-18 FDG PET images.

Computer-assisted lateralization of unilateral temporal lobe epilepsy using Z-score parametric F-18 FDG PET images. Research Abstract Details 

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Computer-assisted lateralization of unilateral temporal lobe epilepsy using Z-score parametric F-18 FDG PET images. Abstract Text:

Ching-Yee Oliver Wong,James Gannon,Jeffrey Bong,Christiana O Wong,Gopal B Saha,

ABSTRACT: BACKGROUND: To evaluate the use of unbiased computer-assisted lateralization of temporal lobe epilepsy (TLE) by z-score parametric PET imaging (ZPET). METHODS: 38 patients with histologically proven unilateral TLE due to pure hippocampal sclerosis, referred for pre-surgical PET evaluation of intractable seizure over a 5-year period, were included. The F-18 FDG images were oriented along temporal long axis and then transformed into ZPET images on a voxel by voxel basis. Multiple regions of interests (21 in total) were placed on cortical, subcortical and cerebellar structures on twenty-eight out of 38 patients with totally seizure-free (class I) outcome. Paired t-tests with Bonferroni correction were used to determine the location of the most asymmetric regions as variables for subsequent discriminant analysis of the entire group of the patients. RESULTS: The computer program identified the anterior half of the temporal lobe (p < 0.0005) and thalami (p = 0.021) as the most asymmetric regions in TLE patients with Class I outcome. Discriminant analysis using z-scores from a total of 8 ROIs (in 4 pairs) on these structures correctly lateralized thirty-seven out of 38 (97%) patients (sensitivity = 94%; specificity = 100%). The only false localization came from a patient with equivocal z-scores on the temporal lobes and this patient turned out to have poor outcome. CONCLUSION: The computer-assisted lateralization of TLE using ZPET provides an accurate, fast and objective way of seizure evaluation.

Computer-assisted lateralization of unilateral temporal lobe epilepsy using Z-score parametric F-18 FDG PET images. Publishing Authors By Initials

CY Wong,J Gannon,J Bong,CO Wong,GB Saha,

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Computer-assisted lateralization of unilateral temporal lobe epilepsy using Z-score parametric F-18 FDG PET images. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: BMC nuclear medicine

VOLUME: 7

Page Numbers: 5

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ISSN: 1471-2385

DAY: 2

MONTH: 11

YEAR: 2007

Computer-assisted lateralization of unilateral temporal lobe epilepsy using Z-score parametric F-18 FDG PET images. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Computer-assisted lateralization of unilateral temporal lobe epilepsy using Z-score parametric F-18 FDG PET images.

AFFILIATION: Nuclear Medicine, William Beaumont Hospital, Royal Oak, MI, USA. owong@beaumont.edu.

Country: England

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MEDLINETA: BMC Nucl Med

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