Computed tomography-based high-dose-rate intracavitary brachytherapy for uterine cervical cancer: preliminary demonstration of correlation between dose-volume parameters and rectal mucosal changes observed by flexible sigmoidoscopy.

Computed tomography-based high-dose-rate intracavitary brachytherapy for uterine cervical cancer: preliminary demonstration of correlation between dose-volume parameters and rectal mucosal changes observed by flexible sigmoidoscopy. Research Abstract Details 

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Computed tomography-based high-dose-rate intracavitary brachytherapy for uterine cervical cancer: preliminary demonstration of correlation between dose-volume parameters and rectal mucosal changes observed by flexible sigmoidoscopy. Abstract Text:

Woong Sub Koom,Dae Kyung Sohn,Joo-Young Kim,Jong Won Kim,Kyung Hwan Shin,Sang Min Yoon,Dae Yong Kim,Myonggeun Yoon,Dongho Shin,Sung Yong Park,Kwan Ho Cho,

PURPOSE: To compare the dose-volume histogram (DVH) parameters obtained by three-dimensional gynecologic brachytherapy planning with the rectosigmoid mucosal changes observed by flexible sigmoidoscopy. METHODS AND MATERIALS: Between January 2004 and July 2005, 71 patients with International Federation of Gynecology and Obstetrics Stage IB-IIIB uterine cervical cancer underwent computed tomography-based high-dose-rate intracavitary brachytherapy. The total dose (external beam radiotherapy [RT] plus intracavitary brachytherapy) to the International Commission of Radiation Units and Measurements rectal point (ICRU(RP)) and DVH parameters for rectosigmoid colon were calculated using the equivalent dose in 2-Gy fractions (alpha/beta = 3 Gy). Sigmoidoscopy was performed every 6 months after RT, with the 6-scale scoring system used to determine mucosal changes. RESULTS: The mean values of the DVH parameters and ICRU(RP) were significantly greater in patients with a score of > or =2 than in those with a score <2 at 12 months after RT (ICRU(RP), 71 Gy(alpha/beta3) vs. 66 Gy(alpha/beta3), p = 0.02; D(0.1cc), 93 Gy(alpha/beta3) vs. 85 Gy(alpha/beta3), p = 0.04; D(1cc), 80 Gy(alpha/beta3) vs. 73 Gy(alpha/beta3), p = 0.02; D(2cc), 75 Gy(alpha/beta3) vs. 69 Gy(alpha/beta3), p = 0.02). The probability of a score of > or =2 showed a significant relationship with the DVH parameters and ICRU(RP) (ICRU(RP), p = 0.03; D(0.1cc), p = 0.05; D(1cc), p = 0.02; D(2cc), p = 0.02). CONCLUSION: Our preliminary data have shown that DVH values of the rectosigmoid colon obtained by computed tomography-based three-dimensional brachytherapy planning are reliable and predictive of score > or =2 rectosigmoid mucosal changes.

Computed tomography-based high-dose-rate intracavitary brachytherapy for uterine cervical cancer: preliminary demonstration of correlation between dose-volume parameters and rectal mucosal changes observed by flexible sigmoidoscopy. Publishing Authors By Initials

WS Koom,DK Sohn,JY Kim,JW Kim,KH Shin,SM Yoon,DY Kim,M Yoon,D Shin,SY Park,KH Cho,

For similar neoplasms: neoplasms by site: urogenital neoplasms: genital neoplasms, female: uterine neoplasms: uterine cervical neoplasms research abstracts see: neoplasms: neoplasms by site: urogenital neoplasms: genital neoplasms, female: uterine neoplasms: uterine cervical neoplasms research

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Computed tomography-based high-dose-rate intracavitary brachytherapy for uterine cervical cancer: preliminary demonstration of correlation between dose-volume parameters and rectal mucosal changes observed by flexible sigmoidoscopy. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: International journal of radiation oncology, biolo

VOLUME: 68

Page Numbers: 1446-54

Journal Abbreviation: Int. J. Radiat. Oncol. Biol. P

ISSN: 0360-3016

DAY: 7

MONTH: 05

YEAR: 2007

Computed tomography-based high-dose-rate intracavitary brachytherapy for uterine cervical cancer: preliminary demonstration of correlation between dose-volume parameters and rectal mucosal changes observed by flexible sigmoidoscopy. Information

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LANGUAGE: eng

NlmUniqueID: 7603616

Computed tomography-based high-dose-rate intracavitary brachytherapy for uterine cervical cancer: preliminary demonstration of correlation between dose-volume parameters and rectal mucosal changes observed by flexible sigmoidoscopy. Keywords Mesh Terms:

KEYWORDS: Uterine Cervical Neoplasms

MESH TERMS: radiotherapy

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Grant and Affiliation Information for Computed tomography-based high-dose-rate intracavitary brachytherapy for uterine cervical cancer: preliminary demonstration of correlation between dose-volume parameters and rectal mucosal changes observed by flexible sigmoidoscopy.

AFFILIATION: Research Institute and Hospital, National Cancer Center, Goyang, Gyeonggi, South Korea.

Country: United States

AGENCY: United States PHS

GRANT: 0610510

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MEDLINETA: Int J Radiat Oncol Biol Phys

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