Computational network model prediction of hemodynamic alterations due to arteriolar remodeling in interval sprint trained skeletal muscle.

Computational network model prediction of hemodynamic alterations due to arteriolar remodeling in interval sprint trained skeletal muscle. Research Abstract Details 

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Computational network model prediction of hemodynamic alterations due to arteriolar remodeling in interval sprint trained skeletal muscle. Abstract Text:

Kyle W Binder,Walter L Murfee,Ji Song,M Harold Laughlin,Richard J Price,

OBJECTIVES: Exercise training is known to enhance skeletal muscle blood flow capacity, with high-intensity interval sprint training (IST) primarily affecting muscles with a high proportion of fast twitch glycolytic fibers. The objective of this study was to determine the relative contributions of new arteriole formation and lumenal arteriolar remodeling to enhanced flow capacity and the impact of these adaptations on local microvascular hemodynamics deep within the muscle. METHODS: The authors studied arteriolar adaptation in the white/mixed-fiber portion of gastrocnemius muscles of IST (6 bouts of running/day; 2.5 min/bout; 60 m/min speed; 15% grade; 4.5 min rest between bouts; 5 training days/wk; 10 wks total) and sedentary (SED) control rats using whole-muscle Microfil casts. Dimensional and topological data were then used to construct a series of computational hemodynamic network models that incorporated physiological red blood cell distributions and hematocrit and diameter dependent apparent viscosities. RESULTS: In comparison to SED controls, IST elicited a significant increase in arterioles/order in the 3A through 6A generations. Predicted IST and SED flows through the 2A generation agreed closely with in vivo measurements made in a previous study, illustrating the accuracy of the model. IST shifted the bulk of the pressure drop across the network from the 3As to the 4As and 5As, and flow capacity increased from 0.7 mL/min in SED to 1.5 mL/min in IST when a driving pressure of 80 mmHg was applied. CONCLUSIONS: The primary adaptation to IST is an increase in arterioles in the 3A through 6A generations, which, in turn, creates an approximate doubling of flow capacity and a deeper penetration of high pressure into the arteriolar network.

Computational network model prediction of hemodynamic alterations due to arteriolar remodeling in interval sprint trained skeletal muscle. Publishing Authors By Initials

KW Binder,WL Murfee,J Song,MH Laughlin,RJ Price,

For similar animals: chordata: vertebrates: mammals: rodentia: muridae: murinae: rats: rats, sprague-dawley research abstracts see: animals: chordata: vertebrates: mammals: rodentia: muridae: murinae: rats: rats, sprague-dawley research

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Computational network model prediction of hemodynamic alterations due to arteriolar remodeling in interval sprint trained skeletal muscle. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Microcirculation (New York, N.Y. : 1994)

VOLUME: 14

Page Numbers: 181-92

Journal Abbreviation:

ISSN: 1073-9688

DAY: 3

MONTH: 12

YEAR: 2007

Computational network model prediction of hemodynamic alterations due to arteriolar remodeling in interval sprint trained skeletal muscle. Information

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LANGUAGE: eng

NlmUniqueID: 9434935

Computational network model prediction of hemodynamic alterations due to arteriolar remodeling in interval sprint trained skeletal muscle. Keywords Mesh Terms:

KEYWORDS: Rats, Sprague-Dawley

MESH TERMS: physiology

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Grant and Affiliation Information for Computational network model prediction of hemodynamic alterations due to arteriolar remodeling in interval sprint trained skeletal muscle.

AFFILIATION: Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia 22908, USA.

Country: United States

AGENCY: United States NHLBI

GRANT: HL66037

ACRONYM: HL

MEDLINETA: Microcirculation

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