Computational models of neocortical neuronogenesis and programmed cell death in the developing mouse, monkey, and human.

Computational models of neocortical neuronogenesis and programmed cell death in the developing mouse, monkey, and human. Research Abstract Details 

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Computational models of neocortical neuronogenesis and programmed cell death in the developing mouse, monkey, and human. Abstract Text:

Julia M Gohlke,William C Griffith,Elaine M Faustman,

This paper presents a computational model allowing quantitative simulations of acquisition of neocortical neuronal number across mammalian species. When extrapolating scientific findings from rodents to humans, it is particularly pertinent to acknowledge the importance of the accelerated enlargement of the neocortex during human evolution. Neocortex development is marked by discrete stages of neural progenitor cell proliferation and death, neuronal differentiation, and neuronal programmed cell death. We have developed computational models of human and rhesus monkey neocortical neuronal cell acquisition based on experimentally derived parameters of cell cycle length, commitment to cell cycle exit, and cell death. Our model results agree with independent stereological studies estimating neocortical neuron number in adult and developing rhesus monkey and human. Comparisons of our primate models with previously developed rodent models suggest correlations between the lengthening of the duration of the neuronogenesis period and a lengthening of the cellular processes of cell cycle progression and death can account for the vast increase in size of the primate neocortex. Furthermore, when compared with rodents, we predict that cell death may play a larger role in shaping the primate neocortex. Our mathematical models of the development and evolution of the neocortex provide a quantitative, biologically based construct for extrapolation between rodent and humans. These models can assist in focusing future experimental research on the differing mechanisms of rodent versus human neocortical development.

Computational models of neocortical neuronogenesis and programmed cell death in the developing mouse, monkey, and human. Publishing Authors By Initials

JM Gohlke,WC Griffith,EM Faustman,

For similar nervous system: neurons research abstracts see: nervous system: neurons research

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Computational models of neocortical neuronogenesis and programmed cell death in the developing mouse, monkey, and human. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Cerebral cortex (New York, N.Y. : 1991)

VOLUME: 17

Page Numbers: 2433-42

Journal Abbreviation: Cereb. Cortex

ISSN: 1047-3211

DAY: 4

MONTH: 01

YEAR: 2007

Computational models of neocortical neuronogenesis and programmed cell death in the developing mouse, monkey, and human. Information

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LANGUAGE: eng

NlmUniqueID: 9110718

Computational models of neocortical neuronogenesis and programmed cell death in the developing mouse, monkey, and human. Keywords Mesh Terms:

KEYWORDS: Neurons

MESH TERMS: physiology

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Grant and Affiliation Information for Computational models of neocortical neuronogenesis and programmed cell death in the developing mouse, monkey, and human.

AFFILIATION: Department of Environmental and Occupational Health Sciences, University of Washington, 4225 Roosevelt Way NE, Seattle, WA 98105, USA.

Country: United States

AGENCY: United States NIEHS

GRANT: R01 ES 10613

ACRONYM: ES

MEDLINETA: Cereb Cortex

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