Compression-induced changes in the physiological state of the breast as observed through frequency domain photon migration measurements.

Compression-induced changes in the physiological state of the breast as observed through frequency domain photon migration measurements. Research Abstract Details 

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Compression-induced changes in the physiological state of the breast as observed through frequency domain photon migration measurements. Abstract Text:

Stefan A Carp,Tina Kauffman,Qianqian Fang,Elizabeth Rafferty,Richard Moore,Daniel Kopans,David Boas,

We use optical spectroscopy to characterize the influence of mammographic-like compression on the physiology of the breast. We note a reduction in total hemoglobin content, tissue oxygen saturation, and optical scattering under compression. We also note a hyperemic effect during repeated compression cycles. By modeling the time course of the tissue oxygen saturation, we are able to obtain estimates for the volumetric blood flow (1.64+/-0.6 mL/100 mL/min) and the oxygen consumption (1.97+/-0.6 micromol/100 mL/min) of compressed breast tissue. These values are comparable to estimates obtained from previously published positron emission tomography (PET) measurements. We conclude that compression-induced changes in breast physiological properties are significant and should be accounted for when performing optical breast imaging. Additionally, the dynamic characteristics of the changes in breast physiological parameters, together with the ability to probe the tissue metabolic state, may prove useful for breast cancer detection.

Compression-induced changes in the physiological state of the breast as observed through frequency domain photon migration measurements. Publishing Authors By Initials

SA Carp,T Kauffman,Q Fang,E Rafferty,R Moore,D Kopans,D Boas,

For similar biomechanics: weight-bearing research abstracts see: biomechanics: weight-bearing research

PUBMED ID PMID:

MEDLINE DATE: 2006 Nov-Dec

Compression-induced changes in the physiological state of the breast as observed through frequency domain photon migration measurements. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Journal of biomedical optics

VOLUME: 11

Page Numbers: 064016

Journal Abbreviation:

ISSN: 1083-3668

DAY: 3

MONTH: 12

YEAR: 2007

Compression-induced changes in the physiological state of the breast as observed through frequency domain photon migration measurements. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9605853

Compression-induced changes in the physiological state of the breast as observed through frequency domain photon migration measurements. Keywords Mesh Terms:

KEYWORDS: Weight-Bearing

MESH TERMS: methods

Chemical & Substance for Abstract: Compression-induced changes in the physiological state of the breast as observed through frequency domain photon migration measurements. Information

Substance Name: Oxygen

Registry Number: 7782-44-7

Grant and Affiliation Information for Compression-induced changes in the physiological state of the breast as observed through frequency domain photon migration measurements.

AFFILIATION: Harvard Medical School, Massachusetts General Hospital, Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, Massachusetts 02129, USA. carp@nmr.mgh.harvard.edu

Country: United States

AGENCY: United States NCI

GRANT: U54-CA104580

ACRONYM: CA

MEDLINETA: J Biomed Opt

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