Components of the Arabidopsis mRNA decapping complex are required for early seedling development.

Components of the Arabidopsis mRNA decapping complex are required for early seedling development. Research Abstract Details 

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Components of the Arabidopsis mRNA decapping complex are required for early seedling development. Abstract Text:

David C Goeres,Jaimie M Van Norman,Weiping Zhang,Nellie A Fauver,Mary Lou Spencer,Leslie E Sieburth,

To understand the mechanisms controlling vein patterning in Arabidopsis thaliana, we analyzed two phenotypically similar mutants, varicose (vcs) and trident (tdt). We had previously identified VCS, and recently, human VCS was shown to function in mRNA decapping. Here, we report that TDT encodes the mRNA-decapping enzyme. VCS and TDT function together in small cytoplasmic foci that appear to be processing bodies. To understand the developmental requirements for mRNA decapping, we characterized the vcs and tdt phenotypes. These mutants were small and chlorotic, with severe defects in shoot apical meristem formation and cotyledon vein patterning. Many capped mRNAs accumulated in tdt and vcs mutants, but surprisingly, some mRNAs were specifically depleted. In addition, loss of decapping arrested the decay of some mRNAs, while others showed either modest or no decay defects, suggesting that mRNAs may show specificity for particular decay pathways (3' to 5' and 5' to 3'). Furthermore, the severe block to postembryonic development in vcs and tdt and the accompanying accumulation of embryonic mRNAs indicate that decapping is important for the embryo-to-seedling developmental transition.

Components of the Arabidopsis mRNA decapping complex are required for early seedling development. Publishing Authors By Initials

DC Goeres,JM Van Norman,W Zhang,NA Fauver,ML Spencer,LE Sieburth,

For similar biochemical phenomena, metabolism, and nutrition: biochemical phenomena: sequence homology: sequence homology, amino acid research abstracts see: biochemical phenomena, metabolism, and nutrition: biochemical phenomena: sequence homology: sequence homology, amino acid research

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Components of the Arabidopsis mRNA decapping complex are required for early seedling development. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: The Plant cell

VOLUME: 19

Page Numbers: 1549-64

Journal Abbreviation: Plant Cell

ISSN: 1040-4651

DAY: 18

MONTH: 05

YEAR: 2007

Components of the Arabidopsis mRNA decapping complex are required for early seedling development. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9208688

Components of the Arabidopsis mRNA decapping complex are required for early seedling development. Keywords Mesh Terms:

KEYWORDS: Sequence Homology, Amino Acid

MESH TERMS: growth & development

Chemical & Substance for Abstract: Components of the Arabidopsis mRNA decapping complex are required for early seedling development. Information

Substance Name: Endoribonucleases

Registry Number: EC 3.1.-

Grant and Affiliation Information for Components of the Arabidopsis mRNA decapping complex are required for early seedling development.

AFFILIATION: Department of Biology, University of Utah, Salt Lake City, Utah 84112, USA.

Country: United States

AGENCY: United States NIGMS

GRANT: 5 T32 GM-007464

ACRONYM: GM

MEDLINETA: Plant Cell

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