Complexity of Depolarization-mediated ERK Phosphorylation in Cerebellar Granule Cells in Primary Cultures.

Complexity of Depolarization-mediated ERK Phosphorylation in Cerebellar Granule Cells in Primary Cultures. Research Abstract Details 

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Complexity of Depolarization-mediated ERK Phosphorylation in Cerebellar Granule Cells in Primary Cultures. Abstract Text:

Liang Peng,Li Gu,Xiaoling Hu,Limei Zhao,Leif Hertz,

We previously showed that cultured mouse cerebellar granule cells during incubation in glutamine-replete medium respond to 45 mM [K(+)](e) after 20 and 60 min incubation with extracellular-signal regulated kinase 1 and 2 (ERK(1/2)) phosphorylation which is mainly, but probably not exclusively, secondary to glutamate release and transactivation of epidermal growth factor (EGF) receptors. In the present study the response after 20 min was shown to be abolished by protein kinase C (PKC) inhibition, whereas that at 60 min was PKC-independent. Addition of 50 muM glutamate to the cells caused ERK(1/2) phosphorylation already after 5 min most of which was sensitive to PKC inhibition although a minor part was PKC inhibition-resistant. Exposure to [K(+)](e) during incubation in glutamine-depleted medium caused no stimulated release of glutamate but a transactivation-independent ERK(1/2) phosphorylation at 20 and 60 min. The response at 20 min was insensitive to PKC inhibition. The potential importance of these complex responses for synaptic plasticity is discussed.

Complexity of Depolarization-mediated ERK Phosphorylation in Cerebellar Granule Cells in Primary Cultures. Publishing Authors By Initials

L Peng,L Gu,X Hu,L Zhao,L Hertz,

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Complexity of Depolarization-mediated ERK Phosphorylation in Cerebellar Granule Cells in Primary Cultures. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Neurochemical research

VOLUME: 33

Page Numbers: 328-35

Journal Abbreviation: Neurochem. Res.

ISSN: 0364-3190

DAY: 13

MONTH: 12

YEAR: 2007

Complexity of Depolarization-mediated ERK Phosphorylation in Cerebellar Granule Cells in Primary Cultures. Information

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LANGUAGE: eng

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AFFILIATION: Department of Clinical Pharmacology, College of Basic Medical Sciences, China Medical University, Shenyang, P.R. China.

Country: United States

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MEDLINETA: Neurochem Res

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